Separation of retinoblastoma and esterase D loci in a patient with sporadic retinoblastoma and del (13) (q14.1q22.3)

A chromosome 13 deletion in a patient with sporadic retinoblastoma appears to have separated the loci for retinoblastoma and esterase D. This study indicates that: (1) the retinoblastoma locus is distinct from the esterase D locus; and (2) the linear order of these genes is centromere-esterase D-ret...

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Bibliographic Details
Published in:Human genetics 1984-01, Vol.68 (3), p.258-259
Main Authors: SPARKES, R. S, SPARKES, M. C, KALINA, R. E, PAGON, R. A, SALK, D. J, DISTECHE, C. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carboxylesterase
Carboxylic Ester Hydrolases - genetics
Child, Preschool
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, 13-15
Female
Genetic Linkage
Hirschsprung Disease - genetics
Humans
Medical sciences
Ophthalmology
Retinoblastoma - enzymology
Retinoblastoma - genetics
Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
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Summary:A chromosome 13 deletion in a patient with sporadic retinoblastoma appears to have separated the loci for retinoblastoma and esterase D. This study indicates that: (1) the retinoblastoma locus is distinct from the esterase D locus; and (2) the linear order of these genes is centromere-esterase D-retinoblastoma.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00418397