Magnesium Deficiency Produces Insulin Resistance and Increased Thromboxane Synthesis

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 1993-06, Vol.21 (6, Part 2), p.1024-1029
• Main Authors: Nadler, Jerry L, Buchanan, Thomas, Natarajan, Rama, Antonipillai, Indra, Bergman, Richard, Rude, Robert
• Format: Article
• Language: English
• Subjects: Aldosterone - blood; Angiotensin II - pharmacology; Biological and medical sciences; Diet; Female; Glucose Tolerance Test; Humans; Injections, Intravenous; Insulin Resistance; Intracellular Membranes - metabolism; Magnesium - blood; Magnesium - pharmacology; Magnesium Deficiency - metabolism; Magnesium Deficiency - physiopathology; Male; Medical sciences; Metabolic diseases; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...); Thromboxane A2 - biosynthesis
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/01.hyp.21.6.1024

Evidence suggests that magnesium deficiency may play an important role in cardiovascular disease. In this study, we evaluated the effects of a magnesium infusion and dietary-induced isolated magnesium deficiency on the production of thromboxane and on angiotensin Il-mediated aldosterone synthesis in normal human subjects. Because insulin resistance may be associated with altered blood pressure, we also measured insulin sensitivity using an intravenous glucose tolerance test with minimal model analysis in six subjects. The magnesium infusion reduced urinary thromboxane concentration and angiotensin II-induced plasma aldosterone levels. The low magnesium diet reduced both serum magnesium and intracellular free magnesium in red blood cells as determined by nuclear magnetic resonance (186±10 [SEM] to 127±9 mM, p