Enhanced interleukin-1beta in hypercholesterolemia: effects of simvastatin and low-dose aspirin

This study was aimed at verifying whether activation of platelets might represent a source of interleukin (IL)-1beta levels in hypercholesterolemia. To this purpose, we compared the effects of a short-term treatment with simvastatin or low-dose aspirin on circulating levels of this cytokine. Fifty p...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-10, Vol.108 (14), p.1673-1675
Main Authors: Ferroni, Patrizia, Martini, Francesca, Cardarello, Cristiano M, Gazzaniga, Pier Paolo, Davi, Giovanni, Basili, Stefania
Format: Article
Language:English
Subjects:
Adult
Aged
Aspirin - administration & dosage
Aspirin - pharmacology
Aspirin - therapeutic use
Female
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - diagnosis
Hypercholesterolemia - drug therapy
Interleukin-1 - blood
Male
Middle Aged
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - pharmacology
Platelet Aggregation Inhibitors - therapeutic use
Simvastatin - pharmacology
Simvastatin - therapeutic use
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Summary:This study was aimed at verifying whether activation of platelets might represent a source of interleukin (IL)-1beta levels in hypercholesterolemia. To this purpose, we compared the effects of a short-term treatment with simvastatin or low-dose aspirin on circulating levels of this cytokine. Fifty patients with hypercholesterolemia were randomly allocated to receive an 8-week therapeutic course of simvastatin 20 mg daily (n=25) or aspirin 100 mg daily (n=25). Baseline soluble (s) P-selectin directly correlated with IL-1beta (P
ISSN:0009-7322
1524-4539