Many patients with Type 1 diabetes estimate their prandial insulin need inappropriately

Background:  Many factors contribute to the need for prandial insulin in Type 1 diabetes. However, patients’ success in achieving normal postprandial glucose concentration is understudied. The aim of the present study was to determine how often patients with Type 1 diabetes achieve normal postprandi...

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Bibliographic Details
Published in:Journal of diabetes 2010-09, Vol.2 (3), p.194-202
Main Authors: AHOLA, Aila J., MÄKIMATTILA, Sari, SARAHEIMO, Markku, MIKKILÄ, Vera, FORSBLOM, Carol, FREESE, Riitta, GROOP, Per-Henrik
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - drug effects
Blood Glucose - metabolism
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Energy Intake
Female
Finland
Humans
Hyperglycemia - epidemiology
Hypoglycemia - epidemiology
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Insulin - administration & dosage
Insulin - therapeutic use
insulin administration
Insulin Infusion Systems
Male
Middle Aged
postprandial glycemia
Postprandial Period
Reproducibility of Results
Sex Characteristics
Type 1 diabetes
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Summary:Background:  Many factors contribute to the need for prandial insulin in Type 1 diabetes. However, patients’ success in achieving normal postprandial glucose concentration is understudied. The aim of the present study was to determine how often patients with Type 1 diabetes achieve normal postprandial glucose concentrations and to evaluate factors associated with postprandial hypo‐ and hyperglycemia. Methods:  Data on food intake, physical activity, insulin administration, and blood glucose concentration were collected using a self‐administered questionnaire from 331 patients with Type 1 diabetes (43% men; mean age 49 ± 12 years; mean diabetes duration 32 ± 13 years). Of these, 179 provided data on blood glucose concentrations measured 110–150 min postprandially. One such meal per patient was randomized for analyses. Results:  Hypoglycemia (
ISSN:1753-0393
1753-0407
DOI:10.1111/j.1753-0407.2010.00086.x