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Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis
Treatment of atopic dermatitis with essential fatty acids remains controversial. A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to re...
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| Published in: | The Lancet (British edition) 1993-06, Vol.341 (8860), p.1557-1560 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1560 |
| container_issue | 8860 |
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| container_title | The Lancet (British edition) |
| container_volume | 341 |
| creator | Berth-Jones, J. Graham-Brown, R.A.C. |
| description | Treatment of atopic dermatitis with essential fatty acids remains controversial. A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis. |
| doi_str_mv | 10.1016/0140-6736(93)90697-F |
| format | article |
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A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(93)90697-F</identifier><identifier>PMID: 8099640</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Allergic diseases ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Atopic dermatitis ; Biological and medical sciences ; Clinical trials ; Dermatitis ; Dermatitis, Atopic - drug therapy ; Double-Blind Method ; Drug Therapy, Combination ; Eczema ; Evening primrose oil ; Fatty acids ; Fatty Acids, Essential - administration & dosage ; Fatty Acids, Essential - therapeutic use ; Female ; Fish oils ; Fish Oils - administration & dosage ; Fish Oils - therapeutic use ; gamma-Linolenic Acid ; Humans ; Immunopathology ; Linoleic Acids ; Lipids ; Male ; Medical research ; Medical sciences ; Oils & fats ; Patients ; Plant Oils ; Skin allergic diseases. 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A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis.</description><subject>Adult</subject><subject>Allergic diseases</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>Clinical trials</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Eczema</subject><subject>Evening primrose oil</subject><subject>Fatty acids</subject><subject>Fatty Acids, Essential - administration & dosage</subject><subject>Fatty Acids, Essential - therapeutic use</subject><subject>Female</subject><subject>Fish oils</subject><subject>Fish Oils - administration & dosage</subject><subject>Fish Oils - therapeutic use</subject><subject>gamma-Linolenic Acid</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Linoleic Acids</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Oils & fats</subject><subject>Patients</subject><subject>Plant Oils</subject><subject>Skin allergic diseases. 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berth-Jones, J.</au><au>Graham-Brown, R.A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1993-06-19</date><risdate>1993</risdate><volume>341</volume><issue>8860</issue><spage>1557</spage><epage>1560</epage><pages>1557-1560</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Treatment of atopic dermatitis with essential fatty acids remains controversial. A double-blind, placebo-controlled, parallel-group study was done to investigate the response of patients with atopic dermatitis to essential fatty acid supplements. Patients with atopic dermatitis were randomised to receive evening primrose oil, evening primrose oil and fish oil, or placebo for 16 weeks. Disease activity was monitored by clinical severity scores recorded by the investigator, topical steroid requirement, and symptom scores recorded by subjects. Of 123 subjects recruited, 102 completed the treatment period. No improvement with active treatment was demonstrated. Our study, which avoided the methodological and analytical problems of previous studies, found no effect of essential fatty acid supplementation in atopic dermatitis.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8099640</pmid><doi>10.1016/0140-6736(93)90697-F</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1993-06, Vol.341 (8860), p.1557-1560 |
| issn | 0140-6736 1474-547X |
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| subjects | Adult Allergic diseases Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Atopic dermatitis Biological and medical sciences Clinical trials Dermatitis Dermatitis, Atopic - drug therapy Double-Blind Method Drug Therapy, Combination Eczema Evening primrose oil Fatty acids Fatty Acids, Essential - administration & dosage Fatty Acids, Essential - therapeutic use Female Fish oils Fish Oils - administration & dosage Fish Oils - therapeutic use gamma-Linolenic Acid Humans Immunopathology Linoleic Acids Lipids Male Medical research Medical sciences Oils & fats Patients Plant Oils Skin allergic diseases. Stinging insect allergies Supplements |
| title | Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis |
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