Tc-99m Labeled Monoclonal Antibodies Against Granulocytes (BW 250/183) in the Detection of Appendicitis

Scintigraphy with Tc-99m labeled antigranulocyte antibodies (BW 250/183 MoABs) was performed in 32 patients with suspected appendicitis. Abdominal imaging (planar/SPECT) was performed 2 hours after injection of the tracer. All patients also had surgery and a histologic examination of the resected ti...

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Bibliographic Details
Published in:Clinical nuclear medicine 1993-05, Vol.18 (5), p.371-376
Main Authors: BIERSACK, HANS J, OVERBECK, BETTINA, OTT, GERHARD, KANIA, ULLRICH, BRIELE, BERND, KROPP, JOACHIM, BOCKISCH, ANDREAS, GRÜNWALD, FRANK, HOTZE, ANDREAS L, HIRNER, ANDREAS, SHIH, WEI JEN
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Appendicitis - diagnostic imaging
Biological and medical sciences
Child
Digestion. Liver. Biliary tract. Spleen. Pancreas
Female
Granulocytes - immunology
Humans
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Leukocytes
Male
Medical sciences
Middle Aged
Organometallic Compounds
Organotechnetium Compounds
Oximes
Oxyquinoline - analogs & derivatives
Radioimmunodetection
Radionuclide investigations
Sensitivity and Specificity
Technetium
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:Scintigraphy with Tc-99m labeled antigranulocyte antibodies (BW 250/183 MoABs) was performed in 32 patients with suspected appendicitis. Abdominal imaging (planar/SPECT) was performed 2 hours after injection of the tracer. All patients also had surgery and a histologic examination of the resected tissue. Of the patients, 17 suffered from “acute appendicitis” and 12 had right positive scans (sensitivity = 70.6%). In 15 patients, acute appendicitis could have been ruled out, and in 11 of these cases the scan was true negative (specificity = 73.3%). The overall accuracy was 71.8% (23/32 cases). The use of Tc-99m antigranulocyte MoABs may overcome the problems associated with the Tc-99m HMPAO granulocyte and ln-111 oxine approaches, which include nonspecific intestinal activity or the lack of timeliness. The use of Tc-99m labeled antigranulocyte antibodies is suitable as an emergency procedure and may play a role in the management of patients with suspected appendicitis.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199305000-00001