Comparison of doubling times of serum carcinoembryonic antigen produced by various metastatic lesions in recurrent gastric and colorectal carcinomas

The authors measured the serial serum carcinoem‐bryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung me‐tastases showed the most prolonged CEA doubling time (CEA‐DT), followed by those with l...

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Bibliographic Details
Published in:Cancer 1993-06, Vol.71 (12), p.4055-4059
Main Authors: Umehara, Yasuhiko, Kimura, Taizou, Yoshida, Masayuki, Oba, Noriyuki, Harada, Yukio
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - secondary
Adenocarcinoma, Papillary - blood
Adenocarcinoma, Papillary - secondary
Aged
Aged, 80 and over
Biological and medical sciences
carcinoembryonic antigen
Carcinoembryonic Antigen - blood
Colonic Neoplasms - blood
colorectal cancer
doubling time
Female
gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Neoplasms - blood
Liver Neoplasms - secondary
Lung Neoplasms - blood
Lung Neoplasms - secondary
Male
Medical sciences
metastasis
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local - blood
Peritoneal Neoplasms - blood
Peritoneal Neoplasms - secondary
Rectal Neoplasms - blood
Stomach Neoplasms - blood
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Time Factors
Tumors
Citations: Items that this one cites
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Summary:The authors measured the serial serum carcinoem‐bryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung me‐tastases showed the most prolonged CEA doubling time (CEA‐DT), followed by those with liver and peritoneal metastases, respectively. Of the 31 patients with recurrent colorectal carcinomas, those with local recurrence showed the most prolonged CEA‐DT, followed by those with lung, liver, and peritoneal metastases, respectively. A positive correlation was observed for gastric and colorectal carcinomas between CEA‐DT in patients with metastatic lesions and outcome (R=0.84 and 0.93, respectively). The results of the current study suggest that postoperative measurement of CEA‐DT is useful in the determination of region of recurrence of carcinoma, which would permit early surgery and chemotherapy. Measurement of CEA‐DT also may be helpful for the accurate determination of prognosis.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19930615)71:12<4055::AID-CNCR2820711241>3.0.CO;2-Q