Constitutive Fragile Sites and Cancer

Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated w...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-12, Vol.226 (4679), p.1199-1204
Main Authors: Yunis, Jorge J., Soreng, A. Lee
Format: Article
Language:English
Subjects:
Acute nonlymphocytic leukemia
Adolescent
Adult
Analysis
Animals
Biological and medical sciences
Blood
Caffeine - pharmacology
Cancer
Cancer research
Carcinogenesis, carcinogens and anticarcinogens
Cells, Cultured
Child
Chromosome breakage
Chromosome Fragile Sites
Chromosome Fragility
Chromosome Mapping
Chromosome replication
Chromosomes
Cultured cells
Female
Floxuridine - pharmacology
Folic Acid - metabolism
Gorilla gorilla
Haploidy
Humans
Leukemia
Lymphocytes
Male
Medical sciences
Middle Aged
Neoplasms - genetics
Oncology, Experimental
Pan troglodytes
Primates
Sarcoma
Thymidine - metabolism
Tumors
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Summary:Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6239375