High-Resolution Proton Nuclear Magnetic Resonance Analysis of Metastatic Cancer Cells

High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-12, Vol.226 (4681), p.1415-1418
Main Authors: Mountford, Carolyn E., Wright, Lesley C., Holmes, Kerry T., Mackinnon, Wanda B., Gregory, Patricia, Fox, Richard M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cancer cells
Cancer metastasis
Cell Line
Cell lines
Cell Membrane - analysis
Cell membranes
Cholesterol esters
Cholesterol Esters - analysis
Clone cells
Dissemination
Lipid research
Lipids
Magnetic Resonance Spectroscopy
Medical sciences
Membrane Lipids - analysis
Metastasis
Neoplasm Metastasis - etiology
Neoplasms, Experimental - analysis
Neoplasms, Experimental - pathology
Nuclear magnetic resonance
Nuclear magnetic resonance spectroscopy
Physiological aspects
Plasma membranes
Proton magnetic resonance spectroscopy
Rats
Rats, Inbred Strains
Spectral resolution
Triglycerides
Triglycerides - analysis
Tumor cell
Tumor cell line
Tumors
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Summary:High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio of cholesterol to phospholipid and an increased amount of plasma membrane--bound cholesterol ester. High-resolution NMR spectroscopy could therefore be used to assess the metastatic potential of primary tumors.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6505699