A Cell Cycle Model Based on the Estrogen-Stimulated Uterus

A cell cycle model is presented for the estrogen-stimulated uterus which is a refinement of the basic cell cycle model developed by Howard and Pelc. The advantage of the new model is that it emphasizes hypertrophy, proliferation and the state of cellular differentiation and allows for an examination...

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Bibliographic Details
Published in:Transactions of the Kansas Academy of Science 1984, Vol.87 (3/4), p.151-155
Main Authors: Lavia, Lynn A., Kelly, Robert W., Roberts, Daniel K.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Cell cycle
Cell Cycle - drug effects
DNA
DNA - biosynthesis
Estradiol - pharmacology
Female
Hypertrophy
Liver
Mitosis
Models, Biological
Ornithine Decarboxylase - metabolism
Protein Biosynthesis
Protein synthesis
Rats
Uterus
Uterus - cytology
Uterus - drug effects
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Summary:A cell cycle model is presented for the estrogen-stimulated uterus which is a refinement of the basic cell cycle model developed by Howard and Pelc. The advantage of the new model is that it emphasizes hypertrophy, proliferation and the state of cellular differentiation and allows for an examination of the events of the cell cycle, especially those of the preDNA synthesis time period. This model can be used to correlate sequential uterine biochemical events as a method of focusing on the correlation of biochemical patterns with other cellular events thus suggesting research questions aimed at discovering possible biochemical functions or points of cycle regulation. The estrogen-stimulated ornithine decarboxylase activity pattern is also discussed as a further cell cycle marker and also as an example of the model's usefulness in raising questions of function.
ISSN:0022-8443
1938-5420
DOI:10.2307/3627851