Estimating medullary chemoreceptor blood flow from ventilatory-CO2 response transients: theory and data from anesthetized dogs

We examined the tracer wash-in technique for measuring blood flow for a specific experimental model in which medullary chemoreceptor blood flow is estimated using carbon dioxide as the tracer. Using a mathematical model, we calculated the flow values that would be estimated when blood flow is a func...

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Bibliographic Details
Published in:Annals of biomedical engineering 1984, Vol.12 (1), p.1-13
Main Authors: ADAMS, J. M, GLASHEEN, W. P, SEVERNS, M. L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carbon Dioxide - blood
Carbon Dioxide - metabolism
Chemoreceptor Cells - blood supply
Dogs
Female
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Miscellaneous
Models, Biological
Regional Blood Flow
Respiration
Citations: Items that this one cites
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Summary:We examined the tracer wash-in technique for measuring blood flow for a specific experimental model in which medullary chemoreceptor blood flow is estimated using carbon dioxide as the tracer. Using a mathematical model, we calculated the flow values that would be estimated when blood flow is a function of the tracer concentration, CO2. The estimate was compared with three indices of time-varying blood flow: the steady-state blood flow before and after the step change of CO2 and the time-average blood flow. Estimated blood flow was found to be most closely related to the final value of flow. Perfusion estimates from five pentobarbital anesthetized dogs were 102 ml/100 g/min (S.D. 35) at an average of PaCO2 of 60.7 Torr.
ISSN:0090-6964
1573-9686
DOI:10.1007/BF02410287