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Average Blood Flow and Oxygen Uptake in the Human Brain During Resting Wakefulness: a Critical Appraisal of the Kety-Schmidt Technique

The Kety–Schmidt technique can be regarded as the reference method for measurement of global average cerebral blood flow (average CBF) and global average cerebral metabolic rate of oxygen (average CMRO2). However, in the practical application of the method, diffusion equilibrium for inert gas tracer...

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Published in:Journal of cerebral blood flow and metabolism 1993-07, Vol.13 (4), p.646-655
Main Authors: Madsen, Peter Lund, Holm, Søren, Herning, Margrethe, Lassen, Niels A.
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description The Kety–Schmidt technique can be regarded as the reference method for measurement of global average cerebral blood flow (average CBF) and global average cerebral metabolic rate of oxygen (average CMRO2). However, in the practical application of the method, diffusion equilibrium for inert gas tracer between the brain and its venous blood is not reached. As a consequence, normal values for CBF and CMRO2 of 54 ml 100 g−1 min−1 and 3.5 ml 100 g−1 min−1 obtained with the Kety–Schmidt technique are an overestimation of the true values. Using the Kety–Schmidt technique we have performed 57 measurements of CBF and CMRO2 during EEG-verified wakeful rest in young normal adults. In order to estimate the equilibrium values for CBF and CMRO2, a simple computer-based simulation model was employed to quantitate the systematic overestimation caused by incomplete tracer equilibrium. When correcting the measured data, we find that the true average values for CBF and CMRO2 in the healthy young adult are ∼46 ml 100 g−1 min−1 and ∼3.0 ml 100 g−1 min−1. Previous studies have suggested that some of the variation in CMRO2 values could be ascribed to differences in cerebral venous anatomy. However in the present study, no correlation between CMRO2 and cerebral venous anatomy as imaged by magnetic resonance angiography could be established. Our data show that the interindividual variation of CMRO2 is 11% (coefficient of variation).
doi_str_mv 10.1038/jcbfm.1993.83
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subjects Adult
Anatomical correlates of behavior
Behavioral psychophysiology
Biological and medical sciences
Brain - metabolism
Cerebral Veins - physiology
Cerebrovascular Circulation
Computer Simulation
Evaluation Studies as Topic
Female
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging
Male
Methods
Oxygen Consumption
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reproducibility of Results
Rest
Wakefulness
title Average Blood Flow and Oxygen Uptake in the Human Brain During Resting Wakefulness: a Critical Appraisal of the Kety-Schmidt Technique
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