Altered blood pressure response to propyldazine after repeated oral administration in conscious normotensive dogs: role of the renin-angiotensin system

The magnitude and the persistence of blood pressure reduction by propyldazine (PDZ) was investigated following treatment over a period of 4 days. The experiments were performed on 6 normotensive dogs trained to submit to puncture of the femoral artery and to stand quietly in a special frame over the...

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Bibliographic Details
Published in:Basic research in cardiology 1984-09, Vol.79 (5), p.588-597
Main Authors: BACHER, S, KRAUPP, O, BECK, A, SEITELBERGER, R, RABERGER, G
Format: Article
Language:English
Subjects:
Administration, Oral
Aldosterone - blood
Animals
Antihypertensive agents
Antihypertensive Agents - pharmacology
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Dihydralazine - pharmacology
Dogs
Dose-Response Relationship, Drug
Female
Heart Rate - drug effects
Homeostasis - drug effects
Male
Medical sciences
Pharmacology. Drug treatments
Pyridazines - pharmacology
Renin - blood
Renin-Angiotensin System - drug effects
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Summary:The magnitude and the persistence of blood pressure reduction by propyldazine (PDZ) was investigated following treatment over a period of 4 days. The experiments were performed on 6 normotensive dogs trained to submit to puncture of the femoral artery and to stand quietly in a special frame over the experimental period of 7 to 8 hours. The first dose effect of orally administered PDZ (0.06, 0.29 and 1.42 mg/kg) on heart rate, arterial blood pressure and plasma renin activity (PRA) was compared with the effect of the substance after treatment at the same respective dosage twice daily over 4 days. The compound caused a dose-dependent decrease in blood pressure accompanied by dose-dependent increases in heart rate and PRA. With 0.06 mg/kg and 0.29 mg/kg PDZ a sustained effect on arterial blood pressure was observed, whereas with 1.42 mg/kg PDZ tolerance occurred after treatment over the 4-day period. A comparison with the effects observed previously with 1.42 and 7.1 mg/kg dihydralazine (DHZ) under identical conditions showed similar results with respect to dose-dependence of blood pressure and counterregulation (1). It is considered that with a low-dose regimen there would be no decrease in activity of PDZ, the long-term hypotensive efficacy of the drug thereby being guaranteed.
ISSN:0300-8428
1435-1803
DOI:10.1007/BF01910488