Effects of 4-hydroxyamphetamine on in vivo brown adipose tissue thermogenesis and feeding behavior in the rat

Examined the influence of 4-hydroxyamphetamine (4-OHAM) on food and water intake and in vivo brown adipose thermogenesis in 2 experiments with 22 female Long-Evans rats. In Exp I, Ss were treated with 4-OHAM (0.25, 0.50, 1, or 2 mg/kg, ip) prior to assessment of interscapular brown adipose tissue (I...

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Bibliographic Details
Published in:Behavioral neuroscience 1984-12, Vol.98 (6), p.1060-1064
Main Authors: Wellman, Paul J, Watkins-Freeman, Patricia A
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - physiology
Amphetamine - pharmacology
AMPHETAMINES
Amphetamines - pharmacology
Animal
Animals
Appetite Depressants - pharmacology
Biological and medical sciences
Body Temperature Regulation - drug effects
BROWN FAT
Drug toxicity and drugs side effects treatment
FEEDING BEHAVIOR
Feeding Behavior - drug effects
Feeding Behavior - physiology
Female
FEMALE ANIMALS
Food Intake
HEAT PRODUCTION
Lipids
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
p-Hydroxyamphetamine - pharmacology
Pharmacology. Drug treatments
RATS
Satiation
Thermoregulation (Body)
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Summary:Examined the influence of 4-hydroxyamphetamine (4-OHAM) on food and water intake and in vivo brown adipose thermogenesis in 2 experiments with 22 female Long-Evans rats. In Exp I, Ss were treated with 4-OHAM (0.25, 0.50, 1, or 2 mg/kg, ip) prior to assessment of interscapular brown adipose tissue (IBAT) thermogenesis. The 4-OHAM treatment induced dose-dependent activation of IBAT thermogenesis consistent with the enhanced serum levels of norepinephrine and epinephrine observed in 4-OHAM-treated Ss immediately after temperature measurement. In Exp II, the influence of 4-OHAM on food and water intake was assessed during 120-min test intervals in Ss fed food and water ad lib. Although there was a trend for 4-OHAM to increase water intake, there was no significant effect of 4-OHAM (0.40, 0.80, 1, 2, and 4 mg/kg) on either food or water intake. Data suggest that IBAT thermogenesis does not play a role in the anorexia induced by amphetamine or in the regulation of feeding. (19 ref)
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.98.6.1060