The effect of ketoconazole on pulmonary pathology associated with dead Dirofilaria immitis

The involvement of thromboxane and lipoxygenase in the regulation of pulmonary lesions and immune responses was investigated in dogs given ketoconazole and exposed to dead adult Dirofiliara immitis. Immunopathological reactions to the dead filariae were monitored by light and transmission electron m...

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Bibliographic Details
Published in:Parasitology research (1987) 1993, Vol.79 (4), p.297-301
Main Authors: TARISH, J, ATWELL, R
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - blood
Biological and medical sciences
Dirofilaria immitis - immunology
Dirofilariasis - drug therapy
Dirofilariasis - immunology
Dirofilariasis - pathology
Dogs
Endothelium, Vascular - pathology
Female
Helminthic diseases
Hemorrhage - parasitology
Infectious diseases
Ketoconazole - therapeutic use
Lung - pathology
Male
Medical sciences
Miscellaneous
Parasitic diseases
Pulmonary Artery - pathology
Pulmonary Fibrosis - parasitology
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Summary:The involvement of thromboxane and lipoxygenase in the regulation of pulmonary lesions and immune responses was investigated in dogs given ketoconazole and exposed to dead adult Dirofiliara immitis. Immunopathological reactions to the dead filariae were monitored by light and transmission electron microscopy and serology. When compared with control tissues, ketoconazole administration enhanced the level of pulmonary haemorrhage and early parenchymal fibrosis associated with dead adult filariae. Ultrastructurally, alveolar capillaries were filled with erythrocyte aggregations and proteinaceous material. These results suggested that an intact thromboxane and lipoxygenase pathway within the arachidonic acid system is necessary to minimize the effect of dead D. immitis in this pulmonary artery model.
ISSN:0932-0113
1432-1955
DOI:10.1007/BF00932185