Intraoperative radiation therapy for patients with pancreatic carcinoma

The results of treatment with intraoperative and external beam radiation for patients with carcinoma of the pancreas are presented. Among patients treated with125I implants for localized unresectable disease, local control rates ranged from 67% to 93% and median survival ranged from 7 to 12 months....

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Bibliographic Details
Published in:World journal of surgery 1984-12, Vol.8 (6), p.929-934
Main Authors: Shipley, William U., Tepper, Joel E., Warshaw, Andrew L., Orlow, Erica L.
Format: Article
Language:English
Subjects:
Beam Radiation
Brachytherapy - methods
Combined Modality Therapy
Electrons
External Beam
External Beam Radiation
Humans
Median Survival
Pancreatectomy
Pancreatic Carcinoma
Pancreatic Neoplasms - radiotherapy
Pancreatic Neoplasms - surgery
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Summary:The results of treatment with intraoperative and external beam radiation for patients with carcinoma of the pancreas are presented. Among patients treated with125I implants for localized unresectable disease, local control rates ranged from 67% to 93% and median survival ranged from 7 to 12 months. In a series using intraoperative electron beam boosts, a 59% local control rate with a median survival of 16 months was achieved. Good palliation rates were achieved, although a high proportion of fatal complications occurred in one125I series. Less promising results were seen in patients receiving intraoperative radiation following resections, with a local control rate of 50% and a median survival of 7 months in a series of 10 patients. Resumen Se presentan los resultados del tratamiento con irradiación intraoperatoria y con irradiación externa para carcinoma de páncreas. Entre los pacientes tratados con implantes de yodo‐125 para enfermedad localizada no resecable, las tasas de control local oscilaron entre 67% y 93% y la supervivencia media varió entre 7 y 12 meses. En una serie en la cual se utilizó una sobredosis intraoperatoria con haz de electrones, se logró una tasa de control local de 59% con una supervivencia media de 16 meses. En una de las series con I‐125 se obtuvieron buenas tasas de paliación, aún cuando hubo una elevada proporción de complicaciones fatales. Resultados menos promisorios fueron observados en una serie de 10 pacientes que recibieron irradiación intraoperatoria después de la resección, con una tasa de control local de 50% y una supervivencia media de 7 meses.
ISSN:0364-2313
1432-2323
DOI:10.1007/BF01656034