The Genain quadruplets: Electrophysiological, positron emission, and x-ray tomographic studies

Four 51-year-old monozygotic quadruplets concordant for schizophrenia, originally studied at the National Institute of Mental Health 25 years ago, were restudied with topographic electroencephalography (EEG), evoked potentials (EPs), computed tomography (CT scans), polysomnographic sleep recordings,...

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Bibliographic Details
Published in:Psychiatry research 1984-09, Vol.13 (1), p.95-108
Main Authors: Buchsbaum, Monte S., Mirsky, Allan F., DeLisi, Lynn E., Morihisa, John, Karson, Craig N., Mendelson, Wallace B., King, Anna C., Johnson, Jeanette, Kessler, Robert
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - diagnostic imaging
Brain - physiopathology
computed tomography
Electroencephalography
evoked potentials
Evoked Potentials, Auditory
Evoked Potentials, Visual
Female
Frontal Lobe - metabolism
genetics
Glucose - metabolism
Humans
Medical sciences
Middle Aged
Miscellaneous
positron emission tomography
Pregnancy
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Quadruplets - psychology
Schizophrenia
Schizophrenia - genetics
Schizophrenia - physiopathology
sleep
Sleep - physiology
Techniques and methods
Tomography, Emission-Computed
Tomography, X-Ray Computed
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Summary:Four 51-year-old monozygotic quadruplets concordant for schizophrenia, originally studied at the National Institute of Mental Health 25 years ago, were restudied with topographic electroencephalography (EEG), evoked potentials (EPs), computed tomography (CT scans), polysomnographic sleep recordings, and positron emission tomography (PET) with 18F-2-deoxyglucose. EEG and EP findings were consistent with those from other groups of patients with schizophrenia and showed great similarity within the quadruplets. CT scans revealed uniformly small lateral ventricles. PET scans replicated earlier findings of relatively low glucose use in the frontal lobes but did not show strong familial concordance.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(84)90121-5