Movable lobes and flexible loops in proteins Structural deformations that control biochemical activity

Two classes of protein whose structure is modified by small ligands are reviewed. Proteins of one group contain two massive domains joined by a flexible link; in response to small molecules, the two lobes approach and enclose the ligand. In the other, a short segment of amino acids moves as a flexib...

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Bibliographic Details
Published in:FEBS Letters 1993-07, Vol.326 (1), p.4-10
Main Author: Kempner, E.S.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Binding Sites
Biological and medical sciences
Domain
Enzyme
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Humans
Ligands
Models, Molecular
Molecular Sequence Data
Molecular Structure
Protein Conformation
Proteins
Proteins - chemistry
Proteins - metabolism
Reaction rate
Structure-Activity Relationship
Structure-function
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Summary:Two classes of protein whose structure is modified by small ligands are reviewed. Proteins of one group contain two massive domains joined by a flexible link; in response to small molecules, the two lobes approach and enclose the ligand. In the other, a short segment of amino acids moves as a flexible loop over the ligand which often is trapped in a non-aqueous environment. Biochemical reaction rates are altered dramatically by these movements.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)81749-P