Preconditioning the human myocardium

Ischaemic preconditioning (short periods of ischaemia with intermittent reperfusion) has been shown paradoxically to protect the myocardium from a subsequent longer iscahemic insult. The protection associated with preconditioning is one of the most powerful mechanisms of protection known and has bee...

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Bibliographic Details
Published in:The Lancet (British edition) 1993-07, Vol.342 (8866), p.276-277
Main Authors: Yellon, D.M, Alkhulaifi, A.M, Pugsley, W.B
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analysis
Animal species
ATP
Biological and medical sciences
Biopsy
Cardiovascular disease
Heart
Humans
Medical research
Medical sciences
Myocardial Ischemia - metabolism
Myocardial Reperfusion
Myocardial Reperfusion Injury - prevention & control
Myocardium - chemistry
Myocardium - pathology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
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Summary:Ischaemic preconditioning (short periods of ischaemia with intermittent reperfusion) has been shown paradoxically to protect the myocardium from a subsequent longer iscahemic insult. The protection associated with preconditioning is one of the most powerful mechanisms of protection known and has been shown in every animal species investigated. However, there is no direct evidence that ischaemic preconditioning occurs in the human heart. We studied wether it was possible to precondition the human heart in a setting of coronary artery bypass surgery. The measurement od adenosine triphosphate in biopsy specimens was used as our endpoint. We believe that our results are the first to show that it may be possible to precondition and protect the human myocardium with short controlled periods of intermitent ischaemia and reperfusion. Lancet 1993; 342: 276–77
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(93)91819-8