Phenotypes of mononuclear cell infiltrates in human central nervous system

Using a panel of monoclonal antibodies applicable for identification of cell types in paraffin sections, the prevalence of mononuclear cell infiltrates with different phenotypes was estimated in large areas taken from 11 cases of acute and chronic inflammatory diseases in the human central nervous s...

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Bibliographic Details
Published in:Acta neuropathologica 1993-05, Vol.85 (6), p.653-657
Main Authors: IWASAKI, Y, SAKO, K, TSUNODA, I, OHARA, Y
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - pathology
Adolescent
Adult
AIDS/HIV
Antibodies, Monoclonal
Biological and medical sciences
Central Nervous System - immunology
Central Nervous System - pathology
Child
Encephalitis, Japanese - pathology
Female
Graft vs Host Disease - pathology
Herpesviridae Infections - pathology
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Monocytes - immunology
Paraparesis, Tropical Spastic - pathology
Phenotype
Rabies - pathology
Subacute Sclerosing Panencephalitis - pathology
Viral diseases
Viral diseases of the nervous system
Virus Diseases - pathology
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Summary:Using a panel of monoclonal antibodies applicable for identification of cell types in paraffin sections, the prevalence of mononuclear cell infiltrates with different phenotypes was estimated in large areas taken from 11 cases of acute and chronic inflammatory diseases in the human central nervous system. The present study clearly demonstrated a diversity of inflammatory mononuclear cell infiltrates, and the dominance of cell types in individual lesions appeared to be determined by both the nature of the diseases and the age of the lesions. The possible pathognomonic significance of a relatively high prevalence of CD4+CD45RO+ lymphocytes in acute rabies and in a convalescent stage of Japanese encephalitis and subacute sclerosing panencephalitis is discussed.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00334676