The relation between class-specific serum rheumatoid factors and age in the general population

• Published in: British journal of rheumatology 1993-07, Vol.32 (7), p.546-549
• Main Authors: VAN SCHAARDENBURG, D, LAGAAY, A. M, OTTEN, H. G, BREEDVELD, F. C
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aging - blood; Aging - immunology; Biological and medical sciences; Diseases of the osteoarticular system; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin A - analysis; Immunoglobulin G - analysis; Immunoglobulin Isotypes - blood; Immunoglobulin Isotypes - classification; Immunoglobulin Isotypes - immunology; Immunoglobulin M - analysis; Inflammatory joint diseases; Male; Medical sciences; Middle Aged; Rheumatoid Factor - blood
• ISSN: 0263-7103; 1460-2172

Class-specific RFs were measured in serum samples obtained from 810 individuals in seven age categories between 20-100 yr old, who were randomly selected from the general population. There was a decline with age of the mean IgG-RF levels in the higher age categories, no change of the mean IgA-RF levels and a clear increase of the mean IgM-RF levels in the higher age categories. In most age categories, the percentage of increased levels of all three RF isotypes was higher in the general population than in the healthy control population, consisting of 100 blood donors. These observations suggest that reference values for serum RF should be age-specific and based on sera of individuals randomly selected from the population.