Single-dose Treatment of Uncomplicated Gonorrhea in Men with Intramuscular and Oral Thiamphenicol

• Published in: Sexually transmitted diseases 1984-10, Vol.11 (4), p.404-406
• Main Authors: PANIKABUTRA, KANCHANA, ARIYARIT, CHARAS, CHITWARAKORN, ANUPONG, SOONTHARARAK, AMPORN, SAENSANOH, CHOOSAK
• Format: Article
• Language: English
• Subjects: Administration, Oral; Drug Evaluation; Gonorrhea - drug therapy; Humans; Injections, Intramuscular; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae - drug effects; Neisseria gonorrhoeae - enzymology; Penicillinase - biosynthesis; Random Allocation; Spectinomycin - administration & dosage; Thiamphenicol - administration & dosage; Uncomplicated Gonococcal Urethritis: Clinical Aspects
• ISSN: 0148-5717; 1537-4521
• DOI: 10.1097/00007435-198410001-00023

Each of 200 men with uncomplicated gonococcal urethritis was randomly assigned to a group receiving one of two therapeutic regimens. Group A received 2 g of spectinomycin intramuscularly. Group B received 2.5 g of thiamphenicol, with 500 mg administered intramuscularly just after oral administration of 2 g. Of the 89 patients in group A who completed the study, 32 were infected with penicillinase-producing Neisseria gonorrhoeae, 49 with non-penicilinase-producing N. gonorrhoeae, and eight with gonococcal strains not tested for penicillinase production. Infection was cured in all 89 patients. Of the 91 patients in group B who completed the study, 33 were infected with penicillinase-producing N. gonorrhoeae, 54 with non-penicillinase-producing N. gonorrhoeae, and four with gonococcal strains not tested for penicillinase production. Infection was cured in 86 (94.5%) of the 91 patients. Thus, the single-dose regimen of thiamphenicol was effective against uncomplicated infections caused by either penicillinase-producing or non-penicillinase-producing strains of N. gonorrhoeae.