A model for malignancy-associated humoral hypercalcemia

Tumor tissue from a patient with squamous cell carcinoma of the lung and hypercalcemia has been serially implanted into athymic mice. Tumor-bearing mice develop cachexia, hypercalcemia without bone metastases, hypophosphatemia, increased urinary cyclic adenosine monophosphate (cAMP) to creatinine ra...

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Bibliographic Details
Published in:Calcified tissue international 1984-12, Vol.36 (5), p.563-567
Main Authors: ABRAMSON, E. C, KUKLA, L. J, SHEVRIN, D. H, LAD, T. E, MCGUIRE, W. P, KUKREJA, S. C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - blood
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - pathology
Disease Models, Animal
General aspects
Humans
Hypercalcemia - etiology
Hypercalcemia - physiopathology
Lung Neoplasms - complications
Lung Neoplasms - pathology
Male
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Minerals - metabolism
Neoplasm Transplantation
Phosphorus - blood
Spine - metabolism
Tumors
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Summary:Tumor tissue from a patient with squamous cell carcinoma of the lung and hypercalcemia has been serially implanted into athymic mice. Tumor-bearing mice develop cachexia, hypercalcemia without bone metastases, hypophosphatemia, increased urinary cyclic adenosine monophosphate (cAMP) to creatinine ratio, and undetectable human immunoreactive parathyroid hormone levels. Radiographs of spines in the tumor-bearing mice demonstrate demineralization, suggesting skeletal resorption as the source of the hypercalcemia. Within 4-8 hours following tumor removal, hypercalcemia is reversed, suggesting that a relatively short-acting humoral substance is responsible for the hypercalcemia. The animals gain weight and become essentially normal within 4 days following tumor removal. The studies demonstrate that this animal model is similar in many aspects to human malignancy-associated humoral hypercalcemia (MAHH) and can provide a useful tool for further investigation of the pathogenesis and treatment of this syndrome.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02405367