Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression

The expression of collagenase messenger RNA (mRNA) and transin mRNA was assessed by Northern blot analysis in well-differentiated benign cells from Dark Agouti rats and in anaplastic carcinoma cells derived from the A5P/B10 cell line. The cells model the opposite extremes in the behavior and morphol...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1993-09, Vol.85 (17), p.1425-1427
Main Authors: Paine, Michael L., Gibbins, John R., Whitelock, John M., O'Grady, Robert L., Kefford, Richard F.
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Carcinoma - enzymology
Carcinoma - genetics
Cells, Cultured
Collagenases - genetics
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Matrix Metalloproteinase 3
Medical research
Metalloendopeptidases - genetics
Rats
RNA, Messenger - analysis
RNA, Neoplasm - analysis
Rodents
Tumor Cells, Cultured
Tumors
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Summary:The expression of collagenase messenger RNA (mRNA) and transin mRNA was assessed by Northern blot analysis in well-differentiated benign cells from Dark Agouti rats and in anaplastic carcinoma cells derived from the A5P/B10 cell line. The cells model the opposite extremes in the behavior and morphology of neoplastic cells observed in tumor progression.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/85.17.1425