Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis

Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological...

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Bibliographic Details
Published in:Rheumatology international 1993-06, Vol.13 (2), p.45-51
Main Authors: Sack, U, Kinne, R W, Marx, T, Heppt, P, Bender, S, Emmrich, F
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - metabolism
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Interleukin-6 - analysis
Interleukin-6 - metabolism
Interleukin-6 - physiology
Male
Middle Aged
Synovial Fluid - chemistry
Synovial Membrane - chemistry
Synovial Membrane - pathology
Synovitis - blood
Synovitis - complications
Synovitis - metabolism
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Summary:Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acute local synovitis (n = 10) was observed. In contrast, SF IL-6 was positively correlated with histological characteristics of chronic synovitis (n = 10; P < or = 0.01) and elevated plasma IgG concentrations (n = 15; P < or = 0.05). In vitro concentrations of IL-6 comparable to those detected in SF increased the production of both IgG and IgM by synovial membrane mononuclear cells. The present results contribute to the view that high local IL-6 concentrations in SF promote chronic synovitis in RA.
ISSN:0172-8172
1437-160X
DOI:10.1007/BF00307733