Pathologic evaluation of sentinel lymph nodes in oral squamous cell carcinoma

Background. The objective of this study was to determine the relative efficacy of different methods of pathologic evaluation of sentinel lymph nodes. Methods. In this prospective study, sentinel nodes were evaluated for occult metastasis using frozen section, imprint‐cytology, hematoxylin‐eosin stai...

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Bibliographic Details
Published in:Head & neck 2010-11, Vol.32 (11), p.1437-1443
Main Authors: Trivedi, Nirav P., Ravindran, Hiran Kattilaparambil, Sundram, Shanmugham, Iyer, Subramania, Kekatpure, Vikram, Durah, Sundeep, Kuriakose, Moni Abraham
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - pathology
Cytological Techniques
Frozen Sections
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
isolated tumor cells
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
lymph node metastasis
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymphatic Metastasis - diagnosis
lymphoscintigraphy
Medical sciences
micrometastasis
occult metastasis
oral squamous cell carcinoma
Otorhinolaryngology. Stomatology
pathology
Predictive Value of Tests
Prospective Studies
Radionuclide Imaging
Sensitivity and Specificity
Sentinel lymph node
Sentinel Lymph Node Biopsy
Staining and Labeling
tongue cancer
Tongue Neoplasms - pathology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background. The objective of this study was to determine the relative efficacy of different methods of pathologic evaluation of sentinel lymph nodes. Methods. In this prospective study, sentinel nodes were evaluated for occult metastasis using frozen section, imprint‐cytology, hematoxylin‐eosin staining, serial step sectioning (SSS) with hematoxylin‐eosin, and immunohistochemistry (IHC). Metastases were classified into macrometastasis (>2.0 mm), micrometastasis (0.2 mm–2.0 mm), isolated tumor cells (
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21345