Homocysteine, Vitamin B12 and Folic Acid Levels in Psoriatic Patients and Correlation with Disease Severity

Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. Th...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2010-07, Vol.23 (3), p.911-916
Main Authors: Brazzelli, V., Grasso, V., Fornara, L., Moggio, E., Gamba, G., Villani, S., Borroni, G.
Format: Article
Language:English
Subjects:
Female
Folic Acid - blood
Homocysteine - blood
Humans
Hyperhomocysteinemia - blood
Male
Middle Aged
Psoriasis - blood
Psoriasis - pathology
Retrospective Studies
Risk Factors
Skin - pathology
Vitamin B 12 - blood
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Summary:Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. The aim of this study is to investigate homocysteine, folic acid and vitamin B12 levels in a cohort of psoriatic patients and its relationship with the severity of the disease. A retrospective observational study in 98 patients with chronic plaque psoriasis and 98 healthy controls was performed. Total plasma homocysteine level, folic acid, vitamin B12 and PASI index were assessed in every patient. Patients with psoriasis had plasma homocysteine levels higher than controls (57% of cases and 25% of controls; p
ISSN:0394-6320
2058-7384
DOI:10.1177/039463201002300327