Effect of sorafenib on experimental choroidal neovascularization in the rat

Purpose:  This study was designed to evaluate the effect of sorafenib administration on laser‐induced experimental choroidal neovascularization (CNV) in rats. Methods:  A total of 36 rats were divided into three groups. Sorafenib, an oral, multitargeted receptor tyrosine kinase inhibitor, was admini...

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Published in:Clinical & experimental ophthalmology 2010-10, Vol.38 (7), p.718-726
Main Authors: Park, Young-Hoon, Roh, Sang Y, Lee, Young-Chun
Format: Article
Language:English
Subjects:
Animals
Benzenesulfonates - administration & dosage
choroidal neovascularization
Choroidal Neovascularization - diagnosis
Choroidal Neovascularization - drug therapy
Choroidal Neovascularization - etiology
Choroidal Neovascularization - metabolism
Computer Systems
Disease Progression
Dose-Response Relationship, Drug
Down-Regulation
Fluorescein Angiography
Gene Expression - drug effects
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
Lasers
Male
Niacinamide - analogs & derivatives
Phenylurea Compounds
Polymerase Chain Reaction
Protein Kinase Inhibitors - administration & dosage
Pyridines - administration & dosage
Radiation Injuries - complications
Rats
Rats, Inbred BN
sorafenib
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
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Summary:Purpose:  This study was designed to evaluate the effect of sorafenib administration on laser‐induced experimental choroidal neovascularization (CNV) in rats. Methods:  A total of 36 rats were divided into three groups. Sorafenib, an oral, multitargeted receptor tyrosine kinase inhibitor, was administered at a dose of 10 mg/kg per day (n = 12) or 30 mg/kg per day (n = 12) for 1 day before the laser induction of CNV. Rats continued to receive the drug for 14 days. Fluorescein angiograms were analysed for CNV dye leakage and the thickness of CNV was assessed by histology. The levels of vascular endothelial growth factor, platelet‐derived growth factor, monocyte chemoattractant protein‐1 and intercellular adhesion molecule‐1 mRNA were measured by the use of real‐time quantitative reverse‐transcription polymerase chain reaction. Results:  Sorafenib‐treated rats had significantly less fluorescence leakage as compared with vehicle‐treated rats (P 
ISSN:1442-6404
1442-9071
DOI:10.1111/j.1442-9071.2010.02328.x