Abnormality of the Delayed Type Hypersensitivity (DTH) Response to Bordetella Pertussis in Spontaneously Hypertensive Rats (SHR)

The delayed type hypersensitivity (DTH) response of spontaneously hypertensive rats (SHR) was compared with that of Wistar Kyoto rats (WKY), a normotensive strain. SHR showed a lower DTH response to Bordetella pertussis than WKY, especially 48 to 72 hr after antigenic challenge. These results were o...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1984, Vol.36(4), pp.449-454
Main Authors: KOMORIYA, Keiji, TSUCHIMOTO, Masahiro, KUNISAWA, Keiko, OKAMIYA, Yoshiaki, TAKESHITA, Torn, NARUCHI, Tatsuyuki, YAMAMOTO, Itaru
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Bordetella pertussis
Bordetella pertussis - immunology
Cardiology. Vascular system
Experimental diseases
Hemolytic Plaque Technique
Hypersensitivity, Delayed - immunology
Hypertension - immunology
Immunization
Levamisole - pharmacology
Male
Medical sciences
Penicillamine - pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
T-Lymphocytes - immunology
T-Lymphocytes - transplantation
Time Factors
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Summary:The delayed type hypersensitivity (DTH) response of spontaneously hypertensive rats (SHR) was compared with that of Wistar Kyoto rats (WKY), a normotensive strain. SHR showed a lower DTH response to Bordetella pertussis than WKY, especially 48 to 72 hr after antigenic challenge. These results were observed before appearance of abnormality of antibody formation or blood pressure. The reduced DTH responses of SHR were partially restored by either transfer of WKY thymocytes or treatment with levamisole. Conversely, the transfer of SHR thymocytes into WKY rats tended to diminish the DTH response. These findings suggest that SHR have a disfunction of'T lymphocytes involved in DTH response (e.g., increase of suppressor cells and/or decrease of helper cells).
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.36.449