Esterase-26 (ES-26): characterization and genetic location on chromosome 3 of an eserine-sensitive esterase of the house mouse (Mus musculus)

Genetic variation of a codominantly inherited esterase, designated ES-26, has been discovered in the house mouse using isoelectric focusing in polyacrylamide gels. The ES-26A phenotype (pI 8.2) was found in C57BL/10Sn. A/J showed the ES-26B phenotype (pI 7.8-7.9). A third phenotype, ES-26C (double-b...

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Bibliographic Details
Published in:Biochemical genetics 1984-12, Vol.22 (11-12), p.1119-1126
Main Authors: VON DEIMLING, O. H, WASSMER, B, MÜLLER, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Electrophoresis, Polyacrylamide Gel
Esterases - genetics
Fundamental and applied biological sciences. Psychology
Genetic Variation
Genetics of eukaryotes. Biological and molecular evolution
Intestine, Small - enzymology
Isoelectric Focusing
Liver - enzymology
Mice
Mice, Inbred Strains - genetics
Phenotype
Physostigmine - pharmacology
Stomach - enzymology
Vertebrata
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Summary:Genetic variation of a codominantly inherited esterase, designated ES-26, has been discovered in the house mouse using isoelectric focusing in polyacrylamide gels. The ES-26A phenotype (pI 8.2) was found in C57BL/10Sn. A/J showed the ES-26B phenotype (pI 7.8-7.9). A third phenotype, ES-26C (double-banded: pI's 8.1 and 8.3), was observed in SJL/J. ES-26 was detected only in liver, stomach, and small intestine. The enzyme was shown to be controlled by the presumed structural locus Es-26, located on chromosome 3. From a four-point cross, the gene order Car-2--6.2 +/- 2.7--Es-16--21.0 +/- 4.5--Es-26--13.6 +/- 3.8--Amy-1 was established.
ISSN:0006-2928
1573-4927
DOI:10.1007/BF00499636