Distribution of SP- and CGRP-immunoreactivity in the cat's larynx

The distribution of substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive (ir) fibres in the cat's larynx was investigated utilizing immunohistochemistry. Many SP- and CGRP-ir fibres with varicosities were found within and below the epithelium and along the basement membran...

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Bibliographic Details
Published in:Journal of laryngology and otology 1993-06, Vol.107 (6), p.522-526
Main Authors: Tanaka, Yasumasa, Yoshida, Yoshikazu, Hirano, Minoru, Morimoto, Masatoshi, Kanaseki, Takeshi
Format: Article
Language:English
Subjects:
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
Animal
Animals
Biological and medical sciences
Calcitonin Gene-Related Peptide - analysis
cat
Cats
Female
Fundamental and applied biological sciences. Psychology
Glottis - chemistry
Hypopharynx - chemistry
Immunoenzyme Techniques
laboratory
Laryngeal Nerves - chemistry
Larynx
Larynx - chemistry
Main Articles
Male
Muscle, Smooth - chemistry
Neuropeptides
Proteins
Substance P - analysis
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Summary:The distribution of substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive (ir) fibres in the cat's larynx was investigated utilizing immunohistochemistry. Many SP- and CGRP-ir fibres with varicosities were found within and below the epithelium and along the basement membrane of the mucosa of all different regions except in the membranous portion of the vocal fold. In the subepithelium, some SP- and CGRP-ir nerve bundles and nerve fibres were recognized around the vessels and glands. In the mucosa, the pattern of distribution and the density of SR-ir fibres were similar to those of CGRP-ir fibres. These reactive fibres were denser in the supraglottic region than in the subglottic region. In the taste bud-like structures, only SP-ir fibres appeared, whereas in the motor endplates, CGRP-reaction was found exclusively. The present findings suggest that the regional distribution of SP- and CGRP-immunoreactivity might be related with sensory and autonomic innervation in the larynx.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100123606