A NEW NEURITOGENETIC COMPOUND BU-4514N PRODUCED BY Microtetraspora sp

A novel neuritogenetic compound BU-4514N was isolated from the fermentation broth of Microtetraspora sp. T689-92. It showed significant NGF-mimic activity and antibacterial activity against Gram-positive bacteria. Structural studies revealed that BU-4514N was a new chemotype antibiotic related to ly...

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Bibliographic Details
Published in:Journal of antibiotics 1993/06/25, Vol.46(6), pp.875-883
Main Authors: TODA, SOICHIRO, YAMAMOTO, SATOSHI, TENMYO, OSAMU, TSUNO, TAKASHI, HASEGAWA, TOSHIFUMI, ROSSER, MARY, OKA, MASAHISA, SAWADA, YOSUKE, KONISHI, MASATAKA, OKI, TOSHIKAZU
Format: Article
Language:English
Subjects:
Actinomycetales - chemistry
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-Positive Bacteria - drug effects
Microbial Sensitivity Tests
Microbiology
microtetraspora
Nerve Growth Factors - chemistry
Neurites
PC12 Cells - drug effects
PC12 Cells - ultrastructure
Pyrrolidinones - chemistry
Pyrrolidinones - isolation & purification
Pyrrolidinones - pharmacology
Tetrahydronaphthalenes - chemistry
Tetrahydronaphthalenes - isolation & purification
Tetrahydronaphthalenes - pharmacology
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Summary:A novel neuritogenetic compound BU-4514N was isolated from the fermentation broth of Microtetraspora sp. T689-92. It showed significant NGF-mimic activity and antibacterial activity against Gram-positive bacteria. Structural studies revealed that BU-4514N was a new chemotype antibiotic related to lydicamycin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.875