Day Care Attendance and Other Risk Factors for Invasive Haemophilus influenzae Type b Disease

Two hundred and ninety-five of 373 (79%) children with reported cases of invasive Haemophilus influenzae type b (Hib) occurring in the state of Oklahoma from January 1, 1986, through December 31, 1987, were matched according to birth date with two controls each. Conditional logistic regression was u...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 1993-09, Vol.138 (5), p.333-340
Main Authors: Arnold, Cody, Makintube, Sue, Istre, Gregory R.
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Bacterial Vaccines - therapeutic use
Biological and medical sciences
Breast Feeding
Child Day Care Centers
Child, Preschool
day care
Haemophilus Infections - etiology
Haemophilus influenzae
Human bacterial diseases
Humans
Infant
Infectious diseases
Medical sciences
meningitis
Oklahoma
Risk Factors
tobacco smoke pollution
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two hundred and ninety-five of 373 (79%) children with reported cases of invasive Haemophilus influenzae type b (Hib) occurring in the state of Oklahoma from January 1, 1986, through December 31, 1987, were matched according to birth date with two controls each. Conditional logistic regression was used to assess the independent roles of day care attendance, number of young children in the home, crowding, passive smoking, maternal education, household income, and race in Hib disease. Statistically significant odds ratios (ORs) were found for day care attendance (OR = 2.9), the presence of two or more children in the home under 6 years of age (OR = 2.4), crowding (ratio of number of people in the home to number of bedrooms ≽2) (OR = 2.0), and exposure to cigarette smoking in the home (OR = 1.4). Household income was independently associated with Hib disease. African Americans were at increased risk even after adjustment for income and crowding (OR = 4.1). Although there were no important differences in risk for other factors by type of Hib disease, there was a large and statistically significant difference in risk for day care attendance between meningitis (adjusted OR = 5.1, 95% confidence interval (Cl) 3.1–8.2) and other types of Hib disease (combining nonmeningitis cases, adjusted OR = 1.6, 95% Cl 0.9–2.7). Increasing numbers of hours per week of day care attendance and children per room were associated with increasing risk of Hib meningitis in a dose-response pattern. The highest day care ORs for meningitis were observed in the youngest (
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a116863