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Effects of Insulin and 1α-Hydroxy Vitamin D3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet
Streptozotocin-induced diabetic rats (LZ-DM rats) developed nephrocalcinosis after being fed a low zinc diet for 4 weeks. However, administration of 1α-hydroxy vitamin D3 (1-OHD3) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD3 was administered...
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| Published in: | Biological & pharmaceutical bulletin 1993/05/15, Vol.16(5), pp.468-470 |
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| container_end_page | 470 |
| container_issue | 5 |
| container_start_page | 468 |
| container_title | Biological & pharmaceutical bulletin |
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| creator | MINAMI, Takeshi SASAKI, Hiroto OKAZAKI, Yuko INOUE, Toru YAMADA, Yuya FUSHIMI, Hisako |
| description | Streptozotocin-induced diabetic rats (LZ-DM rats) developed nephrocalcinosis after being fed a low zinc diet for 4 weeks. However, administration of 1α-hydroxy vitamin D3 (1-OHD3) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD3 was administered to these rats, but decreased in the group receiving insulin. It was also observed that the femur recovered its hardness when insulin was administered, although the hardness in the LZ-DM rats remained lower than that of the control rats. Rat femur hardness, however, did not completely recover with 1-OHD3 treatment.These results indicate that the effects of insulin and 1-OHD3 differ, even though nephrocalcinosis was reduced by administration of either insulin or 1-OHD3. It appears that insulin assists bone formation, and the 1-OHD3 hastens calcium excretion. |
| doi_str_mv | 10.1248/bpb.16.468 |
| format | article |
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However, administration of 1α-hydroxy vitamin D3 (1-OHD3) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD3 was administered to these rats, but decreased in the group receiving insulin. It was also observed that the femur recovered its hardness when insulin was administered, although the hardness in the LZ-DM rats remained lower than that of the control rats. Rat femur hardness, however, did not completely recover with 1-OHD3 treatment.These results indicate that the effects of insulin and 1-OHD3 differ, even though nephrocalcinosis was reduced by administration of either insulin or 1-OHD3. It appears that insulin assists bone formation, and the 1-OHD3 hastens calcium excretion.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.16.468</identifier><identifier>PMID: 8364493</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>1α-hydroxy vitamin D3 ; Animals ; Biological and medical sciences ; Bone and Bones - drug effects ; Bone Development - drug effects ; Calcium - metabolism ; diabetes ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; femur ; General and cellular metabolism. Vitamins ; Hydroxycholecalciferols - pharmacology ; insulin ; Insulin - pharmacology ; low zinc diet ; Male ; Medical sciences ; nephrocalcinosis ; Nephrocalcinosis - prevention & control ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Zinc - deficiency</subject><ispartof>Biological and Pharmaceutical Bulletin, 1993/05/15, Vol.16(5), pp.468-470</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3908290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8364493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MINAMI, Takeshi</creatorcontrib><creatorcontrib>SASAKI, Hiroto</creatorcontrib><creatorcontrib>OKAZAKI, Yuko</creatorcontrib><creatorcontrib>INOUE, Toru</creatorcontrib><creatorcontrib>YAMADA, Yuya</creatorcontrib><creatorcontrib>FUSHIMI, Hisako</creatorcontrib><title>Effects of Insulin and 1α-Hydroxy Vitamin D3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Streptozotocin-induced diabetic rats (LZ-DM rats) developed nephrocalcinosis after being fed a low zinc diet for 4 weeks. However, administration of 1α-hydroxy vitamin D3 (1-OHD3) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD3 was administered to these rats, but decreased in the group receiving insulin. It was also observed that the femur recovered its hardness when insulin was administered, although the hardness in the LZ-DM rats remained lower than that of the control rats. Rat femur hardness, however, did not completely recover with 1-OHD3 treatment.These results indicate that the effects of insulin and 1-OHD3 differ, even though nephrocalcinosis was reduced by administration of either insulin or 1-OHD3. It appears that insulin assists bone formation, and the 1-OHD3 hastens calcium excretion.</description><subject>1α-hydroxy vitamin D3</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - drug effects</subject><subject>Bone Development - drug effects</subject><subject>Calcium - metabolism</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>femur</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hydroxycholecalciferols - pharmacology</subject><subject>insulin</subject><subject>Insulin - pharmacology</subject><subject>low zinc diet</subject><subject>Male</subject><subject>Medical sciences</subject><subject>nephrocalcinosis</subject><subject>Nephrocalcinosis - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Zinc - deficiency</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNo9kUFrGzEUhEVoSVy3l9wDOpTc1pX2rXalY3GSxmAoNEkPvSxvtVIrs5bclZbE-Vf5I_1NFdj48h7MN8xhhpBLzha8rOSXbtcteL2oanlGZhyqphAlF-_IjCkui5oLeUE-xLhhjDWshHNyLqGuKgUz4m6tNTpFGixd-TgNzlP0PeX_3or7fT-Glz396RJus34DNHj6kEazS-E1pKCdL1a-n7Tp6Y3DziSn6Q_MaXdZQboOz_SX8zpDkz6S9xaHaD4d_5w83d0-Lu-L9fdvq-XXdbEplUgFIDALZaOBVb0yAoAj77m0HauV4dJYXlnFG9lrZdEqlMKWIBuNshYMDMzJ9SF3N4a_k4mp3bqozTCgN2GKbSMUA16rbLw6Gqdua_p2N7otjvv22E3mn48co8bBjui1iycbKCbLHDUny4NtExP-NieOY25jMG0ehysFLa9bcTh5pxPVf3BsjYf_PKOJWg</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>MINAMI, Takeshi</creator><creator>SASAKI, Hiroto</creator><creator>OKAZAKI, Yuko</creator><creator>INOUE, Toru</creator><creator>YAMADA, Yuya</creator><creator>FUSHIMI, Hisako</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Effects of Insulin and 1α-Hydroxy Vitamin D3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet</title><author>MINAMI, Takeshi ; SASAKI, Hiroto ; OKAZAKI, Yuko ; INOUE, Toru ; YAMADA, Yuya ; FUSHIMI, Hisako</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j295t-3a30f327c304d9e5331a1d18fb069e18ef14f9178dc9faf9a85f2387ca86503e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>1α-hydroxy vitamin D3</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - drug effects</topic><topic>Bone Development - drug effects</topic><topic>Calcium - metabolism</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>femur</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hydroxycholecalciferols - pharmacology</topic><topic>insulin</topic><topic>Insulin - pharmacology</topic><topic>low zinc diet</topic><topic>Male</topic><topic>Medical sciences</topic><topic>nephrocalcinosis</topic><topic>Nephrocalcinosis - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Zinc - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MINAMI, Takeshi</creatorcontrib><creatorcontrib>SASAKI, Hiroto</creatorcontrib><creatorcontrib>OKAZAKI, Yuko</creatorcontrib><creatorcontrib>INOUE, Toru</creatorcontrib><creatorcontrib>YAMADA, Yuya</creatorcontrib><creatorcontrib>FUSHIMI, Hisako</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MINAMI, Takeshi</au><au>SASAKI, Hiroto</au><au>OKAZAKI, Yuko</au><au>INOUE, Toru</au><au>YAMADA, Yuya</au><au>FUSHIMI, Hisako</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Insulin and 1α-Hydroxy Vitamin D3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>16</volume><issue>5</issue><spage>468</spage><epage>470</epage><pages>468-470</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Streptozotocin-induced diabetic rats (LZ-DM rats) developed nephrocalcinosis after being fed a low zinc diet for 4 weeks. However, administration of 1α-hydroxy vitamin D3 (1-OHD3) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD3 was administered to these rats, but decreased in the group receiving insulin. It was also observed that the femur recovered its hardness when insulin was administered, although the hardness in the LZ-DM rats remained lower than that of the control rats. Rat femur hardness, however, did not completely recover with 1-OHD3 treatment.These results indicate that the effects of insulin and 1-OHD3 differ, even though nephrocalcinosis was reduced by administration of either insulin or 1-OHD3. It appears that insulin assists bone formation, and the 1-OHD3 hastens calcium excretion.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8364493</pmid><doi>10.1248/bpb.16.468</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological and Pharmaceutical Bulletin, 1993/05/15, Vol.16(5), pp.468-470 |
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| language | eng |
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| source | Free Full-Text Journals in Chemistry |
| subjects | 1α-hydroxy vitamin D3 Animals Biological and medical sciences Bone and Bones - drug effects Bone Development - drug effects Calcium - metabolism diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology femur General and cellular metabolism. Vitamins Hydroxycholecalciferols - pharmacology insulin Insulin - pharmacology low zinc diet Male Medical sciences nephrocalcinosis Nephrocalcinosis - prevention & control Pharmacology. Drug treatments Rats Rats, Wistar Zinc - deficiency |
| title | Effects of Insulin and 1α-Hydroxy Vitamin D3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet |
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