Loading…
erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors
Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of th...
Saved in:
| Published in: | European archives of oto-rhino-laryngology 1993, Vol.250 (3), p.150-153 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 153 |
| container_issue | 3 |
| container_start_page | 150 |
| container_title | European archives of oto-rhino-laryngology |
| container_volume | 250 |
| creator | ISSING, W. J DREPS, A HEPPT, W. J WUSTROW, T. P. U RIEDERER, A ZAGURY, J. F |
| description | Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of these genes to neoplasia. One such gene, called erbB-2/Her-2 was found amplified in an adenocarcinoma of the human salivary gland and has also been found associated with primary human breast cancer. Patients with multiple copies of the gene have had a shorter overall survival. In the present study, 21 tumors of the parotid gland were examined by Southern and Northern blot hybridization for amplification and possible overexpression of the erbB-2/Her-2 oncogene. Normal parotid gland tissue was used as negative control. The parotid gland lesions comprised 7 pleomorphic adenomas, 5 squamous cell carcinomas, 4 cases of chronic fibrotic sialadenosis, 3 mucoepidermoid carcinomas as well as 1 lymphoma and 1 cystadenolymphoma. Gene amplification was found in 1 of the pleomorphic adenomas, with 2 tumors showing a significant overexpression of the erbB-2/Her-2 oncogene. Because 3-5% of all pleomorphic adenomas undergo malignant transformation, close follow-up of patients is currently underway. |
| doi_str_mv | 10.1007/bf00171701 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75904256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75904256</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-9b8cf47aa65aebef60cbe0bcd065ab892757b90318060c92488a49355acf50f43</originalsourceid><addsrcrecordid>eNo9kE1LAzEURYMotVY37oVZiAth7MskmWSWtlirFNzoekgySYnMl8lU9N-b0rGrB_ccLo-L0DWGBwzA58oCYI454BM0xZTQlPIsP0VTKAhPKeX8HF2E8AkAjBZkgiYCQyYYm6JX49UizeZr49Ms2ZrWJLLpa2edloPr2kS2VdJ9G29-em9C2EeuTXrpu8FVybbe82HXdD5cojMr62CuxjtDH6un9-U63bw9vywfN6kmORvSQgltKZcyZ9IoY3PQyoDSFcRAiSLjjKsCCBYQUZFRIWR8mjGpLQNLyQzdHXp7333tTBjKxgVt6viK6Xah5KwAmrE8ivcHUfsuBG9s2XvXSP9bYij3w5WL1f9wUb4ZW3eqMdVRHZeK_HbkMmhZWy9b7cJRo4LERkL-ADpvc_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75904256</pqid></control><display><type>article</type><title>erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors</title><source>Springer Online Journal Archives (Through 1996)</source><creator>ISSING, W. J ; DREPS, A ; HEPPT, W. J ; WUSTROW, T. P. U ; RIEDERER, A ; ZAGURY, J. F</creator><creatorcontrib>ISSING, W. J ; DREPS, A ; HEPPT, W. J ; WUSTROW, T. P. U ; RIEDERER, A ; ZAGURY, J. F</creatorcontrib><description>Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of these genes to neoplasia. One such gene, called erbB-2/Her-2 was found amplified in an adenocarcinoma of the human salivary gland and has also been found associated with primary human breast cancer. Patients with multiple copies of the gene have had a shorter overall survival. In the present study, 21 tumors of the parotid gland were examined by Southern and Northern blot hybridization for amplification and possible overexpression of the erbB-2/Her-2 oncogene. Normal parotid gland tissue was used as negative control. The parotid gland lesions comprised 7 pleomorphic adenomas, 5 squamous cell carcinomas, 4 cases of chronic fibrotic sialadenosis, 3 mucoepidermoid carcinomas as well as 1 lymphoma and 1 cystadenolymphoma. Gene amplification was found in 1 of the pleomorphic adenomas, with 2 tumors showing a significant overexpression of the erbB-2/Her-2 oncogene. Because 3-5% of all pleomorphic adenomas undergo malignant transformation, close follow-up of patients is currently underway.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/bf00171701</identifier><identifier>PMID: 8102855</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; DNA, Neoplasm - genetics ; Follow-Up Studies ; Gene Amplification ; Gene Expression Regulation, Neoplastic - genetics ; Humans ; Medical sciences ; Oncogene Proteins, Viral - genetics ; Otorhinolaryngology. Stomatology ; Parotid Neoplasms - genetics ; Receptor, ErbB-2 ; RNA, Neoplasm - genetics ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>European archives of oto-rhino-laryngology, 1993, Vol.250 (3), p.150-153</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4831003$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8102855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISSING, W. J</creatorcontrib><creatorcontrib>DREPS, A</creatorcontrib><creatorcontrib>HEPPT, W. J</creatorcontrib><creatorcontrib>WUSTROW, T. P. U</creatorcontrib><creatorcontrib>RIEDERER, A</creatorcontrib><creatorcontrib>ZAGURY, J. F</creatorcontrib><title>erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of these genes to neoplasia. One such gene, called erbB-2/Her-2 was found amplified in an adenocarcinoma of the human salivary gland and has also been found associated with primary human breast cancer. Patients with multiple copies of the gene have had a shorter overall survival. In the present study, 21 tumors of the parotid gland were examined by Southern and Northern blot hybridization for amplification and possible overexpression of the erbB-2/Her-2 oncogene. Normal parotid gland tissue was used as negative control. The parotid gland lesions comprised 7 pleomorphic adenomas, 5 squamous cell carcinomas, 4 cases of chronic fibrotic sialadenosis, 3 mucoepidermoid carcinomas as well as 1 lymphoma and 1 cystadenolymphoma. Gene amplification was found in 1 of the pleomorphic adenomas, with 2 tumors showing a significant overexpression of the erbB-2/Her-2 oncogene. Because 3-5% of all pleomorphic adenomas undergo malignant transformation, close follow-up of patients is currently underway.</description><subject>Biological and medical sciences</subject><subject>DNA, Neoplasm - genetics</subject><subject>Follow-Up Studies</subject><subject>Gene Amplification</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Oncogene Proteins, Viral - genetics</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Parotid Neoplasms - genetics</subject><subject>Receptor, ErbB-2</subject><subject>RNA, Neoplasm - genetics</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNo9kE1LAzEURYMotVY37oVZiAth7MskmWSWtlirFNzoekgySYnMl8lU9N-b0rGrB_ccLo-L0DWGBwzA58oCYI454BM0xZTQlPIsP0VTKAhPKeX8HF2E8AkAjBZkgiYCQyYYm6JX49UizeZr49Ms2ZrWJLLpa2edloPr2kS2VdJ9G29-em9C2EeuTXrpu8FVybbe82HXdD5cojMr62CuxjtDH6un9-U63bw9vywfN6kmORvSQgltKZcyZ9IoY3PQyoDSFcRAiSLjjKsCCBYQUZFRIWR8mjGpLQNLyQzdHXp7333tTBjKxgVt6viK6Xah5KwAmrE8ivcHUfsuBG9s2XvXSP9bYij3w5WL1f9wUb4ZW3eqMdVRHZeK_HbkMmhZWy9b7cJRo4LERkL-ADpvc_g</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>ISSING, W. J</creator><creator>DREPS, A</creator><creator>HEPPT, W. J</creator><creator>WUSTROW, T. P. U</creator><creator>RIEDERER, A</creator><creator>ZAGURY, J. F</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors</title><author>ISSING, W. J ; DREPS, A ; HEPPT, W. J ; WUSTROW, T. P. U ; RIEDERER, A ; ZAGURY, J. F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-9b8cf47aa65aebef60cbe0bcd065ab892757b90318060c92488a49355acf50f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>DNA, Neoplasm - genetics</topic><topic>Follow-Up Studies</topic><topic>Gene Amplification</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Oncogene Proteins, Viral - genetics</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Parotid Neoplasms - genetics</topic><topic>Receptor, ErbB-2</topic><topic>RNA, Neoplasm - genetics</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISSING, W. J</creatorcontrib><creatorcontrib>DREPS, A</creatorcontrib><creatorcontrib>HEPPT, W. J</creatorcontrib><creatorcontrib>WUSTROW, T. P. U</creatorcontrib><creatorcontrib>RIEDERER, A</creatorcontrib><creatorcontrib>ZAGURY, J. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISSING, W. J</au><au>DREPS, A</au><au>HEPPT, W. J</au><au>WUSTROW, T. P. U</au><au>RIEDERER, A</au><au>ZAGURY, J. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>1993</date><risdate>1993</risdate><volume>250</volume><issue>3</issue><spage>150</spage><epage>153</epage><pages>150-153</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of these genes to neoplasia. One such gene, called erbB-2/Her-2 was found amplified in an adenocarcinoma of the human salivary gland and has also been found associated with primary human breast cancer. Patients with multiple copies of the gene have had a shorter overall survival. In the present study, 21 tumors of the parotid gland were examined by Southern and Northern blot hybridization for amplification and possible overexpression of the erbB-2/Her-2 oncogene. Normal parotid gland tissue was used as negative control. The parotid gland lesions comprised 7 pleomorphic adenomas, 5 squamous cell carcinomas, 4 cases of chronic fibrotic sialadenosis, 3 mucoepidermoid carcinomas as well as 1 lymphoma and 1 cystadenolymphoma. Gene amplification was found in 1 of the pleomorphic adenomas, with 2 tumors showing a significant overexpression of the erbB-2/Her-2 oncogene. Because 3-5% of all pleomorphic adenomas undergo malignant transformation, close follow-up of patients is currently underway.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8102855</pmid><doi>10.1007/bf00171701</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 1993, Vol.250 (3), p.150-153 |
| issn | 0937-4477 1434-4726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75904256 |
| source | Springer Online Journal Archives (Through 1996) |
| subjects | Biological and medical sciences DNA, Neoplasm - genetics Follow-Up Studies Gene Amplification Gene Expression Regulation, Neoplastic - genetics Humans Medical sciences Oncogene Proteins, Viral - genetics Otorhinolaryngology. Stomatology Parotid Neoplasms - genetics Receptor, ErbB-2 RNA, Neoplasm - genetics Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-23T05%3A02%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=erbB-2/Her-2%20gene%20amplification%20and%20overexpression%20in%20parotid%20gland%20tumors&rft.jtitle=European%20archives%20of%20oto-rhino-laryngology&rft.au=ISSING,%20W.%20J&rft.date=1993&rft.volume=250&rft.issue=3&rft.spage=150&rft.epage=153&rft.pages=150-153&rft.issn=0937-4477&rft.eissn=1434-4726&rft_id=info:doi/10.1007/bf00171701&rft_dat=%3Cproquest_cross%3E75904256%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c365t-9b8cf47aa65aebef60cbe0bcd065ab892757b90318060c92488a49355acf50f43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=75904256&rft_id=info:pmid/8102855&rfr_iscdi=true |