Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities

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Bibliographic Details
Published in:Journal of medicinal chemistry 1993-08, Vol.36 (17), p.2575-2577
Main Authors: Chong, Kong Teck, Ruwart, Mary J, Hinshaw, Roger R, Wilkinson, Karen F, Rush, Bob D, Yancey, Mark F, Strohbach, Joseph W, Thaisrivongs, Suvit
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacokinetics
Antiviral Agents - pharmacology
Biological and medical sciences
Half-Life
HIV Protease Inhibitors - chemical synthesis
HIV Protease Inhibitors - pharmacology
human immunodeficiency virus
Humans
Male
Medical sciences
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - pharmacokinetics
Organophosphorus Compounds - pharmacology
Pharmacology. Drug treatments
Prodrugs - chemical synthesis
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm00069a018