Effect of synthetic human pancreatic growth hormone-releasing factors on plasma growth hormone concentrations in lactating cows

Two fragments of human pancreatic growth hormone-releasing factor, hpGRF-(1-24)-NH2 and hpGRF(1-29)-NH2, were administered to lactating dairy cows in separate experiments. Each experiment involved a 4 X 4 Latin square with treatments being intravenous administration of saline (controls) or three dos...

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Bibliographic Details
Published in:Journal of dairy science 1984-12, Vol.67 (12), p.2881-2886
Main Authors: McCutcheon, Stuart N, Bauman, Dale E, Murphy, William A, Lance, Valentine A, Coy, David H
Format: Article
Language:English
Subjects:
Animals
blood composition
bovin laitier
Cattle - metabolism
composicion de la sangre
composition du sang
cows
dairy cattle
Female
ganado de leche
Growth Hormone - blood
Growth Hormone-Releasing Hormone - administration & dosage
Growth Hormone-Releasing Hormone - pharmacology
hormonas liberadoras
hormonas pituitarias
hormone hypophysaire
Injections, Intramuscular - veterinary
Injections, Intravenous - veterinary
Injections, Subcutaneous - veterinary
Lactation - drug effects
Milk - secretion
Peptide Fragments - administration & dosage
Peptide Fragments - pharmacology
pituitary hormones
Pregnancy
releasing hormone
releasing hormones
Sermorelin
vaca
vache
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Summary:Two fragments of human pancreatic growth hormone-releasing factor, hpGRF-(1-24)-NH2 and hpGRF(1-29)-NH2, were administered to lactating dairy cows in separate experiments. Each experiment involved a 4 X 4 Latin square with treatments being intravenous administration of saline (controls) or three doses of releasing factor (500, 1000, and 2000 micrograms). Administration of the 24-amino acid fragment increased plasma growth hormone concentration from baseline 3 ng/ml to peak 14 ng/ml within 10 min. Growth hormone concentrations returned to baseline by 60 min post treatment. The 29-amino acid fragment resulted in greater responses in both peak concentration (30 ng/ml) and persistency (greater than 240 min). Relationships between dose of releasing factor and response in growth hormone release (as measured by area under the response curve) were not consistent in most cows. Responses of concentrations of growth hormone in blood plasma that result from intravenous injection of up to 2000 micrograms of growth hormone-releasing factor (1-29) would not be sufficient to increase milk yield of cows.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(84)81650-1