Treatment of Crohn's disease recurrence after ileoanal anastomosis by azathioprine

Ileoanal anastomosis is a surgical procedure performed in patients with ulcerative colitis. In a small number of patients operated on for ulcerative colitis, Crohn's disease occurs in the reservoir, mimicking pouchitis, and may lead to pouch excision and to a permanent terminal ileostomy. Two p...

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Bibliographic Details
Published in:Digestive diseases and sciences 1993-08, Vol.38 (8), p.1558-1560
Main Authors: BERREBI, W, CHAUSSADE, S, BRUHL, A. L, PARIENTE, A, VALLEUR, P, HAUTEFEUILLE, P, COUTURIER, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anal Canal - surgery
Anastomosis, Surgical
Azathioprine - therapeutic use
Biological and medical sciences
Crohn Disease - therapy
Female
Humans
Ileum - surgery
Immunomodulators
Male
Medical sciences
Pharmacology. Drug treatments
Postoperative Period
Recurrence
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Description
Summary:Ileoanal anastomosis is a surgical procedure performed in patients with ulcerative colitis. In a small number of patients operated on for ulcerative colitis, Crohn's disease occurs in the reservoir, mimicking pouchitis, and may lead to pouch excision and to a permanent terminal ileostomy. Two patients with recurrent Crohn's disease in the reservoir after ileoanal anastomosis were treated with azathioprine for 18 and 24 months, respectively. Azathioprine induced a complete clinical and endoscopic remission. These two observations suggested that immunosuppressive drugs were a good option for permanent ileostomy in cases of recurrence of Crohn's disease in the reservoir after ileoanal anastomosis.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01308621