Biological Basis of Depression in Adults with Diabetes

Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pit...

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Bibliographic Details
Published in:Current diabetes reports 2010-12, Vol.10 (6), p.396-405
Main Authors: Champaneri, Shivam, Wand, Gary S., Malhotra, Saurabh S., Casagrande, Sarah S., Golden, Sherita Hill
Format: Article
Language:English
Subjects:
Animals
Depression - etiology
Depression - metabolism
Depression - physiopathology
Diabetes
Diabetes Complications - complications
Diabetes Mellitus - metabolism
Diabetes Mellitus - physiopathology
Humans
Hypothalamo-Hypophyseal System - metabolism
Hypothalamo-Hypophyseal System - physiopathology
Inflammation - metabolism
Inflammation - physiopathology
Medicine
Medicine & Public Health
Pituitary-Adrenal System - metabolism
Pituitary-Adrenal System - physiopathology
Sympathetic Nervous System - metabolism
Sympathetic Nervous System - physiopathology
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Summary:Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems—HPA axis, SNS, and inflammatory cascade—in depression, diabetes, and diabetes-related risk factors.
ISSN:1534-4827
1539-0829
DOI:10.1007/s11892-010-0148-9