Striatal D2 receptor binding in 22q11 deletion syndrome: an [123I]IBZM SPECT study

It has been hypothesised that in subjects with 22q11 deletion syndrome (22q11DS) disturbances of the dopamine (DA) system contribute to their increased risk for cognitive deficits and psychiatric problems. However, central DAergic neurotransmission in 22q11DS has not been investigated. We measured s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2010-10, Vol.24 (10), p.1525-1531
Main Authors: BOOT, E, BOOIJ, J, ZINKSTOK, J. R, DE HAAN, L, LINSZEN, D. H, BAAS, F, VAN AMELSVOORT, T. A
Format: Article
Language:English
Subjects:
22q11 Deletion Syndrome - blood
22q11 Deletion Syndrome - metabolism
22q11 Deletion Syndrome - physiopathology
Adolescent
Adult
Benzamides
Biological and medical sciences
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Corpus Striatum - metabolism
Corpus Striatum - physiopathology
Dopamine Antagonists
Female
Humans
Iodine Radioisotopes
Male
Medical sciences
Neuropharmacology
Organ Specificity
Pharmacology. Drug treatments
Prolactin - blood
Pyrrolidines
Receptors, Dopamine D2 - metabolism
Severity of Illness Index
Synaptic Transmission
Tomography, Emission-Computed, Single-Photon
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been hypothesised that in subjects with 22q11 deletion syndrome (22q11DS) disturbances of the dopamine (DA) system contribute to their increased risk for cognitive deficits and psychiatric problems. However, central DAergic neurotransmission in 22q11DS has not been investigated. We measured striatal D₂ receptor binding potential (D₂R BP(ND)) using (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide-single photon emission computed tomography ([¹²³I]IBZM SPECT) in 12 adults with 22q11DS and 12 matched controls. Correlations between D₂R BP(ND) and plasma prolactin (pPRL) levels were also determined. 22q11DS subjects and controls had similar D₂R BP( ND). There was a positive correlation between D₂R BP( ND) and pPRL values in controls, but no such relation was found in 22q11DS subjects. This study suggests that a 22q11 deletion does not affect striatal DAergic neurotransmission in the living human brain. However, the disturbed relationship between D₂R BP(ND) and pPRL values suggests DAergic dysfunction at a different level. Further studies on DAergic function in extra-striatal brain regions and under challenged conditions are needed.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881109104854