Ganglioside Pattern of Normal Human Brain, from Samples Obtained at Surgery. A Study Especially Referred to Alkali Labile Species

The ganglioside pattern from normal human temporal cortex and cerebellum has been studied in fresh specimens obtained at surgery. The analyses have been performed by two-dimensional thin layer chromatography with an intermediate ammonia treatment which is a methodology particularly suitable for reso...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 1984-01, Vol.96 (6), p.1943-1946
Main Authors: RIBONI, Laura, MALESCI, Anna, GAINI, Sergio Maria, SONNINO, Sandro, GHIDONI, Riccardo, TETTAMANTI, Guido
Format: Article
Language:English
Subjects:
Aged
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Brain Chemistry
Cerebellum - analysis
Chemical Phenomena
Chemistry
Chromatography, Thin Layer
Fundamental and applied biological sciences. Psychology
Gangliosides - analysis
Gangliosides - isolation & purification
Humans
Hydrogen-Ion Concentration
Lipids
Middle Aged
N-Acetylneuraminic Acid
Other biological molecules
Sialic Acids - analysis
Temporal Lobe - analysis
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Summary:The ganglioside pattern from normal human temporal cortex and cerebellum has been studied in fresh specimens obtained at surgery. The analyses have been performed by two-dimensional thin layer chromatography with an intermediate ammonia treatment which is a methodology particularly suitable for resolving alkali labile gangliosides. Alkali labile gangliosides were detected in all the analyzed specimens and their content contributed to 23% and 11% of total lipid bound sialic acid, in temporal cortex and cerebellum, respectively.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a135030