LIGNIFIED MATERIALS AS MEDICINAL RESOURCES. VI. ANTI-HIV ACTIVITY OF DEHYDROGENATION POLYMER OF p-COUMARIC ACID, A SYNTHETIC LIGNIN, IN A QUASI-IN-VIVO ASSAY SYSTEM AS AN INTERMEDIARY STEP TO CLINICAL TRIALS

After the dehydrogenation polymer of p-coumaric acid, a synthetic lignin, was intravenously injected into mice, the serum was collected immediately, 15 min, 1 h, 5 h, and 24 h after the injection. The serum thus obtained was added to the assay medium containing MT-4 cells infected with HTLV-IIIB (an...

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Published in:Biological & pharmaceutical bulletin 1993/04/15, Vol.16(4), pp.434-436
Main Authors: SHIMIZU, Naoaki, NAOE, Tomoko, KAWAZOE, Yutaka, SAKAGAMI, Hiroshi, NAKASHIMA, Hideki, MURAKAMI, Tsutomu, YAMAMOTO, Naoki
Format: Article
Language:English
Subjects:
AIDS
AIDS/HIV
anti-HIV
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - blood
Antiviral Agents - pharmacology
Biological and medical sciences
Cells, Cultured
Coumaric Acids - blood
Coumaric Acids - pharmacology
Cytopathogenic Effect, Viral - drug effects
dehydrogenation polymer
HIV-1 - drug effects
human immunodeficiency virus
Humans
lignin
Medical sciences
Pharmacology. Drug treatments
Polymers - pharmacology
Propionates
synthetic lignin
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Summary:After the dehydrogenation polymer of p-coumaric acid, a synthetic lignin, was intravenously injected into mice, the serum was collected immediately, 15 min, 1 h, 5 h, and 24 h after the injection. The serum thus obtained was added to the assay medium containing MT-4 cells infected with HTLV-IIIB (an HIV-1 strain). Inhibition of the cytopathogenicity of HIV by these serum preparations was assayed by the MTT method. The result revealed that lignins could be a promising class of anti-HIV agents with an unidentified unique mode of action.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.16.434