Tn, a carcinoma‐associated antigen, reacts with anti‐Tn of normal human sera

Tn antigen is the immediate precursor of the carcinoma (CA)‐associated T antigen; both are masked in non‐CA tissues. Tn antigen was detected by absorption of human anti‐Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn‐positive primary CAs. Thirteen of 25 (52%) a...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1985-02, Vol.55 (3), p.561-569
Main Authors: Springer, Georg F., Taylor, Clive R., Howard, Donald R., Tegtmeyer, Herta, Desai, Parimal R., Murthy, Satya M., Felder, Barbara, Scanlon, Edward F.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antigen-Antibody Reactions
Antigens, Neoplasm - immunology
Antigens, Tumor-Associated, Carbohydrate
Antigens, Viral, Tumor - immunology
Biological and medical sciences
Blood Group Antigens - immunology
Breast Neoplasms - immunology
Carcinoma - immunology
Carcinoma, Intraductal, Noninfiltrating - immunology
Cell Line
Female
Hemagglutination Tests
Histocytochemistry
Host-tumor relations. Immunology. Biological markers
Humans
Immunochemistry
Immunosorbent Techniques
Lymphoma - immunology
Mammary Neoplasms, Experimental - immunology
Medical sciences
Mice
Neoplasm Metastasis
Neoplasm Recurrence, Local
Rats
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tn antigen is the immediate precursor of the carcinoma (CA)‐associated T antigen; both are masked in non‐CA tissues. Tn antigen was detected by absorption of human anti‐Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn‐positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but only 2 of 15 (13%) well differentiated CAs had more Tn than T; 1 anaplastic CA had neither antigen. Eighteen of 20 benign breast lesions had no Tn; the 2 positive lesions were premalignant. All 19 breast CAs, studied immunohistochemically, reacted strongly with human polyclonal anti‐Tn; benign or normal glandular tissues had minimal or no reactivity. Among live cancer cell lines, the most malignant sublines had more Tn than T on their cell surfaces. Preliminary studies with rodent monoclonal anti‐Tn and anti‐T antibodies gave immunohistochemical reactivity patterns similar to those of the polyclonal antibodies, but the former were less sensitive in absorption tests. Tn is a CA marker that promises to be useful in tumor detection.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19850201)55:3<561::AID-CNCR2820550315>3.0.CO;2-1