Mutator plasmid in a nalidixic acid-resistant strain of Shigella dysenteriae type 1

A clinical isolate of Shigella dysenteriae from Kashmir, resistant to seven antibacterial agents including nalidixic acid, carried four plasmids, only one of which was transferable by conjugation. This plasmid, designated pYD1, conferred trimethoprim resistance and increased the frequency of mutatio...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1993-06, Vol.31 (6), p.831-839
Main Authors: Ambler, J. E., Drabu, Y. J., Blakemore, P. H., Pinney, R. J.
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Conjugation, Genetic
DNA Repair
Drug Resistance, Microbial
Escherichia coli - genetics
Escherichia coli - radiation effects
Fundamental and applied biological sciences. Psychology
Genetics
Microbiology
Mutation
Nalidixic Acid - pharmacology
Plasmids
Shigella dysenteriae - drug effects
Shigella dysenteriae - genetics
Ultraviolet Rays
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Summary:A clinical isolate of Shigella dysenteriae from Kashmir, resistant to seven antibacterial agents including nalidixic acid, carried four plasmids, only one of which was transferable by conjugation. This plasmid, designated pYD1, conferred trimethoprim resistance and increased the frequency of mutation to nalidixic acid resistance in recipient strains. Thus, although nalidixic acid resistance was not carried on a transferable plasmid, the presence of pYD1 increased the frequency at which the strain mutated to nalidixic acid resistance
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/31.6.831