Prolactin cell carcinoma of the pituitary. Clinicopathologic, immunohistochemical, and ultrastructural study of a case with cranial and extracranial metastases

A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high‐dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly...

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Bibliographic Details
Published in:Cancer 1985-02, Vol.55 (3), p.598-604
Main Authors: Scheithauer, Bernd W., Randall, Raymond V., Laws, Edward R., Kovacs, Kalman T., Horvath, Eva, Whitaker, Michael D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Assay
Brain Neoplasms - pathology
Brain Neoplasms - secondary
Bromocriptine - therapeutic use
Combined Modality Therapy
Endocrinopathies
Ergolines - therapeutic use
Female
Histocytochemistry
Hormones - analysis
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Malignant tumors
Medical sciences
Microscopy, Electron
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Pergolide
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Pituitary Neoplasms - therapy
Prolactin - analysis
Prolactin - blood
Prolactin - metabolism
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Summary:A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high‐dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immunohistochemical studies demonstrated prolactin in the cytoplasm of primary and metastatic tumor cells. Ultrastructural features of lactotrophic differentiation, including misplaced granule exocytosis, were observed. This is the third reported case of prolactin cell carcinoma that metastasized despite high‐dose dopamine agonist therapy. Analysis of the patient's serum prolactin showed no abnormality in the chromatographic profile of biologic activity.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19850201)55:3<598::AID-CNCR2820550320>3.0.CO;2-S