MK-801 changes the role of glutamic acid on modulation of algesia in nucleus accumbens

Dizocilpine maleate (MK-801) causes the blockage of the glutamic acid (Glu) receptors in the central nervous system that are involved in pain transmission. However, the mechanism of action of MK-801 in pain-related neurons is not clear, and it is still unknown whether Glu is involved in the modulati...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2010-05, Vol.395 (3), p.407-411
Main Authors: Shi, Tie-feng, Yang, Chun-xiao, Yang, Dong-xiao, Jiao, Run-sheng, Zhang, Guang-wen, Gao, He-ren, Zhang, Duo, Xu, Man-ying
Format: Article
Language:English
Subjects:
Algesia
Analgesics - pharmacology
Animals
Dizocilpine maleate
Dizocilpine Maleate - pharmacology
Glutamic acid
Glutamic Acid - physiology
Male
Neurons - drug effects
Neurons - physiology
Nucleus accumbens
Nucleus Accumbens - cytology
Nucleus Accumbens - drug effects
Nucleus Accumbens - physiology
Pain - physiopathology
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - physiology
Synaptic Transmission - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dizocilpine maleate (MK-801) causes the blockage of the glutamic acid (Glu) receptors in the central nervous system that are involved in pain transmission. However, the mechanism of action of MK-801 in pain-related neurons is not clear, and it is still unknown whether Glu is involved in the modulation of this processing. This study examines the effect of MK-801, Glu on the pain-evoked response of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the nucleus accumbens (NAc) of rats. The trains of electric impulses applied to the sciatic nerve were used as noxious stimulation. The electrical activities of PENs or PINs in NAc were recorded by a glass microelectrode. Our results revealed that the lateral ventricle injection of Glu increased the discharged frequency and shortened the discharged latency of PEN, and decreased the discharged frequency and prolonged the discharged inhibitory duration (ID) of PIN in NAc of rats evoked by the noxious stimulation, while intra-NAc administration of MK-801 produced the opposite response. On the basis of above findings we can deduce that Glu, MK-801 and N-methyl- d-aspartate (NMDA) receptor are involved in the modulation of nociceptive information transmission in NAc.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2010.04.034