Locus coeruleus neuronal activity during the sleep-waking cycle in mice

Abstract Using extracellular single-unit recordings in nonanesthetized, head-restrained mice, we examined spontaneous and evoked discharges of noradrenaline-containing locus coeruleus (NA-LC) neurons across the sleep-waking cycle. The neurons were all characterized by triphasic broad action potentia...

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Bibliographic Details
Published in:Neuroscience 2010-09, Vol.169 (3), p.1115-1126
Main Authors: Takahashi, K, Kayama, Y, Lin, J.S, Sakai, K
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Action potential
Action Potentials
Animals
arousal
Biological and medical sciences
disfacilitation
Fundamental and applied biological sciences. Psychology
locus coeruleus
Locus Coeruleus - physiology
Male
Mice
Mice, Inbred C57BL
Neurology
Neurons - physiology
Norepinephrine - metabolism
Reaction Time
single unit recording
Sleep - physiology
sleep-waking switch
Sleep. Vigilance
Vertebrates: nervous system and sense organs
Wakefulness - physiology
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Summary:Abstract Using extracellular single-unit recordings in nonanesthetized, head-restrained mice, we examined spontaneous and evoked discharges of noradrenaline-containing locus coeruleus (NA-LC) neurons across the sleep-waking cycle. The neurons were all characterized by triphasic broad action potentials. They discharged as either slow (
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2010.06.009