Effect of probiotics enriched diet on Paralichthys olivaceus infected with lymphocystis disease virus (LCDV)

We report the effect of two probiotics, Lactobacil and Sporolac as separate or mixed diets on innate immune mechanisms, such as phagocytosis activity, superoxide anion production of blood leukocytes, complement activity and plasma lysozyme activity, and disease resistance in lymphocystis disease vir...

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Bibliographic Details
Published in:Fish & shellfish immunology 2010-11, Vol.29 (5), p.868-874
Main Authors: Harikrishnan, Ramasamy, Balasundaram, Chellam, Heo, Moon-Soo
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Aquaculture - methods
Dietary Supplements
DNA Virus Infections - drug therapy
DNA Virus Infections - immunology
DNA Virus Infections - veterinary
Fish Diseases - drug therapy
Fish Diseases - immunology
Fish Diseases - virology
Flounder
Immunity, Innate - drug effects
Iridoviridae - immunology
Lymphocystis disease virus
Marine
Muramidase - blood
Nonspecific immune parameter
Paralichthys olivaceus
Phagocytosis - drug effects
Phagocytosis - immunology
Pleuronectiformes
Probiotics
Probiotics - administration & dosage
Probiotics - pharmacology
Probiotics - therapeutic use
Superoxides - metabolism
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Summary:We report the effect of two probiotics, Lactobacil and Sporolac as separate or mixed diets on innate immune mechanisms, such as phagocytosis activity, superoxide anion production of blood leukocytes, complement activity and plasma lysozyme activity, and disease resistance in lymphocystis disease virus (LCDV) infected olive flounder, Paralichthys olivaceus (523.5 ± 18.3 g) on week 1, 2, and 4. In infected fish, administration of diet supplemented with Lactobacil individually or mixed with Sporolac significantly enhanced the immune parameters like phagocytic activity superoxide anion production, complement activity, and plasma lysozyme. However administration of supplemented diet with Sporolac alone, all the chosen immune parameters did not enhance when compared to control group; this diets resulted in lower mortality (30% and 25%) than Sporolac diet group (45%) in 30 days. We conclude that Lactobacil individually or mixed with Sporolac act as immunostimulants that enhance the innate immune response and disease resistance in lymphocystis disease virus (LCDV) infected olive flounder.
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2010.07.031