Removal of albumin-bound toxins from albumin-containing solutions: Tryptophan fixed-bed adsorption on activated carbon

Fixed-bed adsorption on activated carbon is a common blood detoxification technique implemented in liver support devices to remove different types of toxins, among which is tryptophan. In this paper, fixed-bed adsorption kinetics of tryptophan on activated carbon were investigated. Experimental tryp...

Full description

Saved in:
Bibliographic Details
Published in:Chemical engineering research & design 2010-08, Vol.88 (8), p.1018-1023
Main Authors: Annesini, M.C., Piemonte, V., Turchetti, L.
Format: Article
Language:English
Subjects:
Accounting
Activated carbon
Adsorption
Albumin
Applied sciences
Chemical engineering
Chemical engineers
Exact sciences and technology
Fixed-bed adsorption
Heat and mass transfer. Packings, plates
Liver support
Mathematical models
Toxins
Tryptophan
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fixed-bed adsorption on activated carbon is a common blood detoxification technique implemented in liver support devices to remove different types of toxins, among which is tryptophan. In this paper, fixed-bed adsorption kinetics of tryptophan on activated carbon were investigated. Experimental tryptophan breakthrough curves were obtained at different feed flow rates, both in albumin-free and albumin-containing solutions. A mathematical model based on linear driving force mass transfer kinetics was used to correlate data obtained with albumin-free solutions; subsequently, the results were successfully used to predict tryptophan breakthrough curves obtained with albumin-containing solutions, accounting only for the effect of albumin over tryptophan adsorption equilibrium.
ISSN:0263-8762
DOI:10.1016/j.cherd.2010.01.022