Relationships between proteasomes and viral gene products

The interrelationships between proteasomes and viral gene products are very complex. 20S proteasomes associate with a number of viral mRNAs which are cleaved by proteasome's associated endonuclease activity. In addition proteasome's endopeptidase activities are involved in the presentation...

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Bibliographic Details
Published in:Molecular biology reports 1999-04, Vol.26 (1-2), p.113-117
Main Authors: Jarrousse, A S, Gautier, K, Apcher, S, Badaoui, S, Boissonnet, G, Dadet, M H, Henry, L, Bureau, J P, Schmid, H P, Petit, F
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - metabolism
AIDS/HIV
Antigen presentation
Cysteine Endopeptidases - metabolism
Endonuclease
endopeptidase
Enzymatic activity
Enzymes
HIV
HIV - metabolism
HIV Long Terminal Repeat
Human immunodeficiency virus
Humans
mRNA
Multienzyme Complexes - metabolism
Proteasome Endopeptidase Complex
proteasomes
RNA, Messenger - metabolism
RNA, Transfer, Amino Acyl - metabolism
RNA, Viral - metabolism
Viral Proteins - metabolism
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Summary:The interrelationships between proteasomes and viral gene products are very complex. 20S proteasomes associate with a number of viral mRNAs which are cleaved by proteasome's associated endonuclease activity. In addition proteasome's endopeptidase activities are involved in the presentation of viral antigens. Viral proteins of different origin associate with the 20S and 26S complexes and interfere with their enzymatic activities. A major part of this review deals with the interactions between 20S proteasomes and the gene products of the human immunodeficiency virus (HIV) which has been studied in detail by our group.
ISSN:0301-4851
1573-4978
DOI:10.1023/A:1006982023524